MOUNTAIN
RESEARCH
CENTER

Polytechnic Institute
of Bragança

image01

CIMO

CIMO - Mountain Research Center. See video HERE

FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.

Sandrina Alves Heleno

Assistant Researcher
Group: Sustainable Processes and Products
Phone: 273303285
E-mail: sheleno@ipb.pt
ORCID: 000-0001-7224-1098
Scopus Author ID: 30067731800

Career

  • Since 2023: Auxiliary researcher at the Mountain Research Center of the Polytechnic Institute of Bragança (CIMO-IPB), Portugal
  • 2019 - 2023: Junior Researcher (national funding by FCT, Foundation dor Science and Tecnhology) at the Mountain Research Center of the Polytechnic Institute of Bragança (CIMO-IPB), Portugal
  • 2015 - 2019: Pos-Doc researcher (SFRH/BPD/101413/2014)
  • 2015 - 2015: Pos-Doc researcher in the project ( NORTE-07-0124-FEDER- 0000014) - Polymer Reaction Engineering, Laboratory of Separation and Reaction Engineering, at the Mountain Research Center of the Polytechnic Institute of Bragança (CIMO-IPB), Portugal

Qualifications

  • 2014 - PhD. in Sciences, speciality in chemistry, University of Minho (UM), Portugal
  • 2010 - MSc. in Biotechnology, Polytechnic Institute of Bragança (IPB), Portugal
  • 2008 - Graduation in Biotechnological Engineering, Polytechnic Institute of Bragança (IPB), Portugal

Awards and Honors

  • 2024 - “The best of the year 2023” award: Winning project in the Innovation/Research category of the year with the PreVineGrape project: Development of a biofungicide to combat grapevine diseases; Revista vinhos.
  • 2023 - Distinction – list of most cited authors, a ranking resulting from a study carried out by Stanford University (USA) - database of most cited scientists that provides standardized information on citations, h-index, hm-index adjusted for co-authorship , citations of articles in different authorship positions and a composite indicator (c-score). Career-wide data is updated to the end of 2021, and recent single-year data refers to citations during calendar year 2021. Selection is based on the top 100,000 scientists by c-score (with and without self-citations ) or a percentile rank of 2% or greater in the subfield
  • 2022 - Distinction – Integration of the 4th edition of the book Mulheres na Ciência. Centro de Ciência viva, Lisbon, Portugal
  • 2022 - Promove Program (2020-2021) - Initiative B - Ideas with the potential to become innovative pilot projects
  • 2022 - Distinction – list of most cited authors, a ranking resulting from a study carried out by Stanford University (USA) - database of most cited scientists that provides standardized information on citations, h-index, hm-index adjusted for co-authorship , citations of articles in different authorship positions and a composite indicator (c-score). Career-wide data is updated to the end of 2021, and recent single-year data refers to citations during calendar year 2021. Selection is based on the top 100,000 scientists by c-score (with and without self-citations ) or a percentile rank of 2% or greater in the subfield
  • 2019 - Distinction - Winner of the Born from Knowledge Caixa Agrícola Distinction. “ChestWine” project. Lisbon, Portugal
  • 2019 - National Award – Winner of the Caixa Agrícola Entrepreneurship and Innovation award, in the Production, Transformation and Marketing category. “ChestWine” project, Portugal
  • 2017 - Ward for the best oral communication in the VIII Fórum Ibérico de Úlceras e Feridas, Guimarães, Portugal

Interests

  • Extraction, purification and characterization of bioactive compounds
  • Development of biostimulants, biofungicides of natural origin
  • Vines and wines
  • Elicitation of mushroom´s bioactives and nutrients
  • Development of Bio-based Sport beverages
  • Functional agents for the food and beverage industries
  • Bio-based antimicrobials

Projects:

TextBlueStyle - Obtenção de corantes azuis naturais e sustentáveis para aplicação têxtil
Funding body: Promove LA CAIXA
Reference:
Principal Investigator:Calhelha, Ricardo C.
Start: 2023-07-01
End: 2026-06-30
WOODLANDFUNGI - Valorização e Sustentabilidade dos Cogumelos Silvestres do Barroso
Funding body: Promove LA CAIXA
Reference:
Principal Investigator:Carla Susana Correia Pereira
Start: 2023-06-30
End: 2025-05-31
PulpIng - Development of Pumpking Pulp Formulations using a Sustainable Integrated Strategy
Funding body: PRIMA
Reference: PRIMA/0007/2019
Principal Investigator:Barros, Lillian
Start: 2020-09-01
End: 2024-08-31
Aquavitae - Thermal water as a source of life and health
Funding body: Promove LA CAIXA
Reference: PD20-00003
Principal Investigator:Barros, Lillian
Start: 2021-09-01
End: 2024-05-31
WASTESILK - Silk Sericin as an industrial wastewater with valuable biomedical potential
Funding body: FCT
Reference: PTDC/BTA-BTA/0696/2020
Principal Investigator:Barros, Lillian
Start: 2021-03-29
End: 2024-03-28
RevestCAST - Otimização dos processos industriais de aplicação de revestimentos comestíveis para a conservação pós-colheita da castanha (Castanea sativa)
Funding body: PORTUGAL 2020
Reference: POCI-01-0247-FEDER-049276
Principal Investigator:Barros, Lillian
Start: 2021-01-31
End: 2023-06-30
Bio4drinks - Obtenção de Ingredientes Naturais Multifuncionais para a Indústria de Bebidas
Funding body: NORTE 2020
Reference: NORTE-01-0247-FEDER-113508
Principal Investigator:Sandrina Alves Heleno
Start: 2021-09-01
End: 2023-06-30
PreVineGrape - Desenvolvimento de um biofungicida para combate a doenças da videira
Funding body: PORTUGAL 2020
Reference: POCI-01-0247-FEDER-049695
Principal Investigator:Sandrina Alves Heleno
Start: 2021-01-01
End: 2023-06-29
VALORNATURAL - Valorização de Recursos Naturais através da Extração de Ingredientes de Elevado Valor Acrescentado para Aplicações na Indústria Alimentar
Funding body: NORTE 2020
Reference: NORTE-01-0247-FEDER-024479
Principal Investigator:Barros, Lillian
Start: 2018-09-01
End: 2022-08-31
PlantCovid - Aplicações de extratos de plantas com ação dirigida ao SARS-CoV-2
Funding body: NORTE 2020
Reference: NORTE-01-02B/-FEDER-054870
Principal Investigator:Barros, Lillian
Start: 2020-07-14
End: 2021-12-31
Halófitas Vermelhas - Halófitas vermelhas como nova fonte de biomoléculas com aplicação na indústria alimentar, nutracêutica e medicina
Funding body: Programa bilateral Portugal/Tunísia
Reference:
Principal Investigator:Barreira, João C.M.
Start: 2019-01-01
End: 2020-12-31

Total results: 124
1
Lima L.,Pereira A.I.,Vaz C.B.,Ferreira O.,Dias M.I.,Heleno S.A.,Calhelha R.C.,Barros L.,Carocho M.
Optimization of heat and ultrasound-assisted extraction of Eucalyptus globulus leaves reveals strong antioxidant and antimicrobial properties
Food Chemistry, 479, , 2025

2
de Oliveira I.,Santos-Buelga C.,Aquino Y.,Barros L.,Heleno S.A.
New frontiers in the exploration of phenolic compounds and other bioactives as natural preservatives
Food Bioscience, 68, , 2025

3
Fernandes F.A.,Roriz C.,Calhelha R.C.,Rodrigues P.,Pires T.C.S.P.,Prieto M.A.,Ferreira I.C.F.R.,Barros L.,Heleno S.A.
Valorization of natural resources - development of a functional plant-based beverage
Food Chemistry, 472, , 2025

4
Shiraishi C.S.H.,Roriz C.L.,Carocho M.,Prieto M.A.,Abreu R.M.V.,Barros L.,Heleno S.A.
Blockchain revolution in food supply chains: A positive impact on global food loss and waste
Food Chemistry, 467, , 2025

5
Ribeiro J.,Silva V.,Igrejas G.,Barros L.,Heleno S.A.,Reis F.S.,Poeta P.
Phenolic Compounds from Pyrus communis Residues: Mechanisms of Antibacterial Action and Therapeutic Applications
Antibiotics, 14, , 2025

6
Plasencia P.,Finimundy T.C.,Carocho M.,Calhelha R.C.,Añibarro-Ortega M.,Pires T.C.S.P.,Barreiro F.,Garcia P.A.,Barros L.,Heleno S.A.
Extraction of Bioactive Compounds from Rubus Idaeus Bioresidues: A Full Screening on Phenolic Composition and Bioactive Potential
Waste and Biomass Valorization, 16, 737-747, 2025

7
Desiderio A.,Pedrosa M.C.,Heleno S.A.,Carocho M.,Rodrigues D.B.,Buratti S.,Soffientini I.,Ratto D.,Savino E.,Rossi P.
Bio-Recycling Hazelnut Shells to Improve Antioxidant Properties of Lentinus tigrinus Sporophore
Agriculture (Switzerland), 15, , 2025

8
Albuquerque B.R.,Pinela J.,Pereira C.,Calhelha R.C.,Oliveira I.,Heleno S.,Oliveira M.B.P.P.,Barros L.
Optimization and comparison of heat- and ultrasound-assisted extraction methods for anthocyanin recovery from Sicana odorifera fruit epicarp
Biomass Conversion and Biorefinery, 15, 1027-1040, 2025

9
Fernandes F.A.,Oliveira P.A.,Pinto M.L.,Venâncio C.,Félix L.,Medeiros-Fonseca B.,Correia R.,Prieto M.A.,Ferreira I.C.F.R.,Barros L.,Heleno S.A.
Effects of a Cyperus esculentus L. plant-based beverage on FVB/n female mice
Food and Chemical Toxicology, 194, , 2024

10
Radhouane M.F.,da Silveira T.F.F.,Ribeiro J.,Rodrigues P.,Guimarães R.,Calhelha R.,Mandim F.,Charfi I.,Ferreira I.C.F.R.,Alves M.J.,Barros L.,Heleno S.A.
Development, characterization and stability of a novel sport drink based on thermal water, apple juice and hibiscus
Food Chemistry Advances, 5, , 2024

11
12
da Silveira T.F.F.,Hasni J.,Portelada N.,Fernandes F.A.,Rodrigues P.,Lemos A.,Ferreira I.C.F.R.,Alves M.J.,Barros L.,Heleno S.A.
Development and characterisation of gluten-free fresh pasta using teff, rice, and buckwheat flours enhanced with thermal waters: a mixture design approach
International Journal of Food Science and Technology, 59, 8351-8360, 2024

13
Mandim F.,Petropoulos S.A.,Pinto C.A.,Heleno S.A.,Rodrigues P.,Dias M.I.,Saraiva J.A.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.,Pinela J.
Novel cold and thermally pasteurized cardoon-enriched functional smoothie formulations: A zero-waste manufacturing approach
Food Chemistry, 456, , 2024

14
Ferreira F.,Guimarães R.,Lemos A.,Milho C.,da Silveira T.F.F.,Ueda J.M.,Carocho M.,Heleno S.A.,Barros L.,Ferreira I.C.F.R.,Pintado M.,Alves M.J.
Harnessing the Power of Natural Mineral Waters in Bread Formulations: Effects on Chemical, Physical, and Physicochemical Properties
Applied Sciences (Switzerland), 14, , 2024

15
Pires L.,Gonzalez-Paramás A.M.,Heleno S.A.,Calhelha R.C.
Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health
Applied Sciences (Switzerland), 14, , 2024

16
de Oliveira I.,Chrysargyris A.,Finimundy T.C.,Carocho M.,Santos-Buelga C.,Calhelha R.C.,Tzortzakis N.,Barros L.,Heleno S.A.
The influence of magnesium and manganese cations on the chemical and bioactive properties of purple and green basil
Food and Function, 15, 10644-10662, 2024

17
Pires L.,González-Paramás A.M.,Heleno S.A.,Calhelha R.C.
Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Antibiotics, 13, , 2024

18
Fernandes F.A.,Carocho M.,Prieto M.A.,Barros L.,Ferreira I.C.F.R.,Heleno S.A.
Nutraceuticals and dietary supplements: balancing out the pros and cons
Food and Function, 15, 6289-6303, 2024

19
Pires L.,González-Paramás A.M.,Heleno S.A.,Calhelha R.C.
The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases
Antibiotics, 13, , 2024

20
21
Sosa D.,Alves F.M.,Prieto M.A.,Pedrosa M.C.,Heleno S.A.,Barros L.,Feliciano M.,Carocho M.
Lemna minor: Unlocking the Value of This Duckweed for the Food and Feed Industry
Foods, 13, , 2024

22
de Oliveira I.,Chrysargyris A.,Finimundy T.C.,Carocho M.,Santos-Buelga C.,Calhelha R.C.,Tzortzakis N.,Barros L.,Heleno S.A.
Magnesium and manganese induced changes on chemical, nutritional, antioxidant and antimicrobial properties of the pansy and Viola edible flowers
Food Chemistry, 438, , 2024

23
Pedrosa M.C.,Ueda J.M.,Heleno S.A.,Carocho M.,Reis F.S.,Ferreira I.C.F.R.,Barros L.
Value-Added Lipids from Plant Foods and Respective Applications
Food Byproducts Management and Their Utilization, 91-126, 2024

24
Chtioui W.,Heleno S.,Migheli Q.,Rodrigues P.
Plant extracts as biocontrol agents against Aspergillus carbonarius growth and ochratoxin A production in grapes
International Journal of Food Microbiology, 407, , 2023

25
Ueda J.M.,Morales P.,Fernández-Ruiz V.,Ferreira A.,Barros L.,Carocho M.,Heleno S.A.
Powdered Foods: Structure, Processing, and Challenges: A Review
Applied Sciences (Switzerland), 13, , 2023

26
Ueda J.M.,Griebler K.R.,Finimundy T.C.,Rodrigues D.B.,Veríssimo L.,Pires T.C.S.P.,Gonçalves J.,Fernandes I.P.,Pereira E.,Barros L.,Heleno S.A.,Calhelha R.C.
Polyphenol Composition by HPLC-DAD-(ESI-)MS/MS and Bioactivities of Extracts from Grape Agri-Food Wastes
Molecules, 28, , 2023

27
Albuquerque B.R.,Pinela J.,Pereira C.,Mandim F.,Heleno S.,Oliveira M.B.P.P.,Barros L.
Recovery of anthocyanins from Eugenia spp. fruit peels: a comparison between heat- and ultrasound-assisted extraction
Sustainable Food Technology, 2, 189-201, 2023

28
Plasencia P.,Heleno S.A.,Finimundy T.,Carocho M.,Calhelha R.C.,Añibarro-Ortega M.,Alves M.J.,Oludemi T.,Quidiongo N.,Barreiro F.,García P.A.,Ferreira I.C.F.R.,Barros L.
Recovery of High Valuable Bioactive Molecules from Vaccinium myrtillus L. Bioresidues
Waste and Biomass Valorization, 14, 2873-2884, 2023

29
Roriz C.L.,Carocho M.,Alves M.J.,Rodrigues P.,Morales P.,Ferreira I.C.F.R.,Heleno S.A.,Barros L.
Betacyanins obtained from alternative novel sources as natural food colorant additives: incorporated in savory and sweet food products
Food and Function, 14, 8775-8784, 2023

30
Martins de Deus B.,Fernandes C.,Molina A.K.,Xavier V.,Pires T.C.S.P.,Mandim F.,Heleno S.A.,Finimundy T.C.,Barros L.
Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives
Plants, 12, , 2023

31
de Oliveira I.,Chrysargyris A.,Heleno S.A.,Carocho M.,Calhelha R.C.,Dias M.I.,Petrović J.,Soković M.,Petropoulos S.A.,Santos-Buelga C.,Tzortzakis N.,Barros L.
Effects of the extraction techniques on the chemical composition and bioactive properties of lemon balm (Melissa officinalis L.) plants grown under different cropping and irrigation regimes
Food Research International, 170, , 2023

32
Rodrigues D.B.,Veríssimo L.,Finimundy T.,Rodrigues J.,Oliveira I.,Gonçalves J.,Fernandes I.P.,Barros L.,Heleno S.A.,Calhelha R.C.
Chemical and Bioactive Screening of Green Polyphenol-Rich Extracts from Chestnut By-Products: An Approach to Guide the Sustainable Production of High-Added Value Ingredients
Foods, 12, , 2023

33
Inumaro R.S.,Casalvara R.F.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Calhelha R.M.,Heleno S.A.,Pimentel T.C.,Gonçalves J.E.,Cardozo-Filho L.
Supercritical fluid-assisted extraction of hop cone residue from craft breweries
Journal of CO2 Utilization, 72, , 2023

34
Castillo A.,Finimundy T.C.,Heleno S.A.,Rodrigues P.,Fernandes F.A.,Pereira S.,Lores M.,Barros L.,Garcia-Jares C.
The generally recognized as safe (GRAS) microalgae Haematococcus pluvialis (wet) as a multifunctional additive for coloring and improving the organoleptic and functional properties of foods
Food and Function, 14, 6023-6035, 2023

35
Mediavilla I.,Bados R.,Barros L.,Xavier V.,Finimundy T.C.,Pires T.C.S.P.,Heleno S.A.,Calhelha R.C.,Amaral J.S.,Rizzo A.M.,Casini D.,Lombardi G.,Chiaramonti D.,Cámara M.,Suárez A.,Ardid T.,Esteban L.S.
Assessment of the Use of Common Juniper (Juniperus communis L.) Foliage following the Cascade Principle
Molecules, 28, , 2023

36
Shiraishi C.S.H.,Zbiss Y.,Roriz C.L.,Dias M.I.,Prieto M.A.,Calhelha R.C.,Alves M.J.,Heleno S.A.,da Cunha Mendes V.,Carocho M.,Abreu R.M.V.,Barros L.
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes, 11, , 2023

37
38
Carocho M.,Heleno S.A.,Barros L.
Natural Secondary Metabolites: From Nature, Through Science, to Industry
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 1-965, 2023

39
Hached H.,Cassani L.,Zbiss Y.,Fraga-Corral M.,Oliveira I.,Pereira A.G.,Prieto M.A.,Heleno S.A.,Carocho M.
Non-alkaloid nitrogen-containing compounds from fungi
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 627-646, 2023

40
Liberal Â.,Cardoso R.V.C.,Heleno S.A.,Fernandes Â.,Barros L.,Martins A.
Phenolic Acids from Fungi
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 475-495, 2023

41
de Oliveira I.,Albuquerque B.,Ueda J.M.,Alves M.J.,Ferreira I.C.F.R.,Barros L.,Heleno S.A.
New challenges and opportunities from secondary metabolites
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 925-965, 2023

42
Carocho M.,Heleno S.A.,Barros L.
Preface
Natural Secondary Metabolites: From Nature, Through Science, to Industry, v, 2023

43
Xavier V.,Spréa R.,Finimundy T.C.,Heleno S.A.,Amaral J.S.,Barros L.,Ferreira I.C.F.R.
Terpenes
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 107-156, 2023

44
Calhelha R.C.,Haddad H.,Ribeiro L.,Heleno S.A.,Carocho M.,Barros L.
Inflammation: What’s There and What’s New?
Applied Sciences (Switzerland), 13, , 2023

45
Heleno S.A.,Carocho M.,Reis F.S.,Pires T.C.S.P.,Pintado M.,Ferreira I.C.F.R.,Barros L.
Plant Extracts and SARS-CoV-2: Research and Applications
Life, 13, , 2023

46
Barros L.,Heleno S.A.,Prieto M.A.
Natural Products as Health Promoters
Current Pharmaceutical Design, 29, 803, 2023

47
Ueda J.M.,Milho C.,Heleno S.A.,Soria-Lopez A.,Carpena M.,Alves M.J.,Pires T.,Prieto M.A.,Simal-Gandara J.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.
Emerging Strategies to Combat Methicillin-resistant Staphylococcus aureus (MRSA): Natural Agents with High Potential
Current Pharmaceutical Design, 29, 837-851, 2023

48
Zaier M.M.,Heleno S.A.,Mandim F.,Calhelha R.C.,Ferreira I.C.F.R.,Achour L.,Kacem A.,Dias M.I.,Barros L.
Effects of the seasonal variation in the phytochemical composition and bioactivities of the wild halophyte Suaeda fruticosa
Food Bioscience, 50, , 2022

49
Durazzo A.,Carocho M.,Heleno S.A.,Pedrosa M.C.,Ueda J.M.,Barros L.,Souto E.B.,Santini A.,Lucarini M.
Fermented food/beverage and health: current perspectives
Rendiconti Lincei, 33, 729-738, 2022

50
de la Fuente B.,Pinela J.,Calhelha R.C.,Heleno S.A.,Ferreira I.C.F.R.,Barba F.J.,Berrada H.,Caleja C.,Barros L.
Sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) head oils recovered by microwave-assisted extraction: Nutritional quality and biological properties
Food and Bioproducts Processing, 136, 97-105, 2022

51
Polyzos N.,Paschoalinotto B.H.,Compocholi M.,Pinela J.,Heleno S.A.,Calhelha R.C.,Dias M.I.,Barros L.,Petropoulos S.A.
Fertilization of Pot-Grown Cichorium spinosum L.: How It Can Affect Plant Growth, Chemical Profile, and Bioactivities of Edible Parts?
Horticulturae, 8, , 2022

52
Durazzo A.,Carocho M.,Heleno S.,Barros L.,Souto E.B.,Santini A.,Lucarini M.
Food dyes and health: Literature quantitative research analysis
Measurement: Food, 7, , 2022

53
Alonso-Esteban J.I.,Carocho M.,Barros D.,Velho M.V.,Heleno S.,Barros L.
Chemical composition and industrial applications of Maritime pine (Pinus pinaster Ait.) bark and other non-wood parts
Reviews in Environmental Science and Biotechnology, 21, 583-633, 2022

54
de la Fuente B.,Pinela J.,Mandim F.,Heleno S.A.,Ferreira I.C.F.R.,Barba F.J.,Berrada H.,Caleja C.,Barros L.
Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction
Food Chemistry, 386, , 2022

55
Fernandes F.A.,Pedrosa M.C.,Ueda J.M.,Ferreira E.,Rodrigues P.,Heleno S.A.,Carocho M.,Prieto M.A.,Ferreira I.C.F.R.,Barros L.
Improving the physicochemical properties of a traditional Portuguese cake - “económicos” with chestnut flour
Food and Function, 13, 8243-8253, 2022

56
Fernandes F.A.,Heleno S.A.,Pinela J.,Carocho M.,Prieto M.A.,Ferreira I.C.F.R.,Barros L.
Recovery of Citric Acid from Citrus Peels: Ultrasound-Assisted Extraction Optimized by Response Surface Methodology
Chemosensors, 10, , 2022

57
Ueda J.M.,Pedrosa M.C.,Heleno S.A.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Food Additives from Fruit and Vegetable By-Products and Bio-Residues: A Comprehensive Review Focused on Sustainability
Sustainability (Switzerland), 14, , 2022

58
Derbassi N.,C. Pedrosa M.,Heleno S.,Fernandes F.,Dias M.I.,Calhelha R.C.,Rodrigues P.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Arbutus unedo leaf extracts as potential dairy preservatives: case study on quark cheese
Food and Function, 13, 5442-5454, 2022

59
Derbassi N.B.,Pedrosa M.C.,Heleno S.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Plant volatiles: Using Scented molecules as food additives
Trends in Food Science and Technology, 122, 97-103, 2022

60
Roriz C.L.,Heleno S.A.,Alves M.J.,Oliveira M.B.P.P.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Red pitaya (Hylocereus costaricensis) peel as a source of valuable molecules: Extraction optimization to recover natural colouring agents
Food Chemistry, 372, , 2022

61
Xavier V.,Finimundy T.C.,Heleno S.A.,Amaral J.S.,Calhelha R.C.,Vaz J.,Pires T.C.S.P.,Mediavilla I.,Esteban L.S.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive characterization of the essential oils obtained from three mediterranean plants
Molecules, 26, , 2021

62
Pedrosa M.C.,Lima L.,Heleno S.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Food metabolites as tools for authentication, processing, and nutritive value assessment
Foods, 10, , 2021

63
Vega E.N.,Molina A.K.,Pereira C.,Dias M.I.,Heleno S.A.,Rodrigues P.,Fernandes I.P.,Barreiro M.F.,Stojković D.,Soković M.,Carocho M.,Barreira J.C.M.,Ferreira I.C.F.R.,Barros L.
Anthocyanins from rubus fruticosus l. And morus nigra l. applied as food colorants: A natural alternative
Plants, 10, , 2021

64
Ceccanti C.,Finimundy T.C.,Heleno S.A.,Pires T.C.S.P.,Calhelha R.C.,Guidi L.,Ferreira I.C.F.R.,Barros L.
Differences in the phenolic composition and nutraceutical properties of freeze dried and oven-dried wild and domesticated samples of Sanguisorba minor Scop
LWT, 145, , 2021

65
Roriz C.L.,Xavier V.,Heleno S.A.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive features of amaranthus caudatus l. Flowers and optimized ultrasound-assisted extraction of betalains
Foods, 10, , 2021

66
Ueda J.M.,Pedrosa M.C.,Fernandes F.A.,Rodrigues P.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.A.,Carocho M.,Ineu R.P.,Ferreira I.C.F.R.,Barros L.
Promising preserving agents from sage and basil: A case study with yogurts
Foods, 10, , 2021

67
Gómez-Mejía E.,Roriz C.L.,Heleno S.A.,Calhelha R.,Dias M.I.,Pinela J.,Rosales-Conrado N.,León-González M.E.,Ferreira I.C.F.R.,Barros L.
Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential
Food Chemistry, 337, , 2021

68
Albuquerque B.R.,Heleno S.A.8.,Oliveira M.B.P.P.,Barros L.,Ferreira I.C.F.R.
Phenolic compounds: Current industrial applications, limitations and future challenges
Food and Function, 12, 14-29, 2021

69
Pedrosa M.C.,Ueda J.M.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.,da Silva A.B.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Preservation of chocolate muffins with Lemon Balm, Oregano, and Rosemary extracts
Foods, 10, , 2021

70
Roriz C.L.,Heleno S.A.,Carocho M.,Rodrigues P.,Pinela J.,Dias M.I.,Fernandes I.P.,Barreiro M.F.,Morales P.,Barros L.,Ferreira I.C.F.R.
Betacyanins from Gomphrena globosa L. flowers: Incorporation in cookies as natural colouring agents
Food Chemistry, 329, , 2020

71
Sampaio S.L.,Petropoulos S.A.,Alexopoulos A.,Heleno S.A.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
Potato peels as sources of functional compounds for the food industry: A review
Trends in Food Science and Technology, 103, 118-129, 2020

72
Carocho M.,Morales P.,Ciudad-Mulero M.,Fernández-Ruiz V.,Ferreira E.,Heleno S.,Rodrigues P.,Barros L.,Ferreira I.C.F.R.
Comparison of different bread types: Chemical and physical parameters
Food Chemistry, 310, , 2020

73
Fernandes F.A.,Carocho M.,Heleno S.A.,Rodrigues P.,Dias M.I.,Pinela J.,Prieto M.A.,Simal-Gandara J.,Barros L.,Ferreira I.C.F.R.
Effect of natural preservatives on the nutritional profile, chemical composition, bioactivity and stability of a nutraceutical preparation of aloe arborescens
Antioxidants, 9, , 2020

74
Martins N.,Heleno S.A.,Ferreira I.C.F.R.
An upcoming approach to alzheimer's disease: Ethnopharmacological potential of plant bioactive molecules
Current Medicinal Chemistry, 27, 4344-4371, 2020

75
Corrêa R.C.G.,Heleno S.A.,Alves M.J.,Ferreira I.C.F.R.
Bacterial resistance: antibiotics of last generation used in clinical practice and the arise of natural products as new therapeutic alternatives
Current Pharmaceutical Design, 26, 815-837, 2020

76
Molina A.K.,Vega E.N.,Pereira C.,Dias M.I.,Heleno S.A.,Rodrigues P.,Fernandes I.P.,Barreiro M.F.,Kostić M.,Soković M.,Barreira J.C.M.,Barros L.,Ferreira I.C.F.R.
Promising antioxidant and antimicrobial food colourants from Lonicera caerulea L. var. Kamtschatica
Antioxidants, 8, , 2019

77
Rached W.,Barros L.,Ziani B.E.C.,Bennaceur M.,Calhelha R.C.,Heleno S.A.,Alves M.J.,Marouf A.,Ferreira I.C.F.R.
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.
Food and Function, 10, 5898-5909, 2019

78
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity
Microchemical Journal, 147, 469-477, 2019

79
Cardoso R.V.C.,Fernandes Â.,Heleno S.A.,Rodrigues P.,Gonzaléz-Paramás A.M.,Barros L.,Ferreira I.C.F.R.
Physicochemical characterization and microbiology of wheat and rye flours
Food Chemistry, 280, 123-129, 2019

80
Mandim F.,Barros L.,Heleno S.A.,Pires T.C.S.P.,Dias M.I.,Alves M.J.,Santos P.F.,Ferreira I.C.F.R.
Phenolic profile and effects of acetone fractions obtained from the inflorescences of: Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteria
Food and Function, 10, 2399-2407, 2019

81
Carocho M.,Heleno S.,Rodrigues P.,Barreiro M.F.,Barros L.,Ferreira I.C.F.R.
A novel natural coating for food preservation: Effectiveness on microbial growth and physicochemical parameters
LWT, 104, 76-83, 2019

82
Rudke A.R.,Heleno S.A.,Fernandes I.P.,Prieto M.A.,Gonçalves O.H.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Microencapsulation of ergosterol and Agaricus bisporus L. extracts by complex coacervation using whey protein and chitosan: Optimization study using response surface methodology
LWT, 103, 228-237, 2019

83
Ziani B.E.C.,Heleno S.A.,Bachari K.,Dias M.I.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
Phenolic compounds characterization by LC-DAD- ESI/MSn and bioactive properties of Thymus algeriensis Boiss. & Reut. and Ephedra alata Decne
Food Research International, 116, 312-319, 2019

84
Da Silva R.F.R.,Barreira J.C.M.,Heleno S.A.,Barros L.,Calhelha R.C.,Ferreira I.C.F.R.
Anthocyanin profile of elderberry juice: A natural-based bioactive colouring ingredient with potential food application
Molecules, 24, , 2019

85
Mandim F.,Barros L.,Calhelha R.C.,Abreu R.M.V.,Pinela J.,Alves M.J.,Heleno S.,Santos P.F.,Ferreira I.C.F.R.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

86
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile
Industrial Crops and Products, 124, 44-52, 2018

87
Almeida H.H.S.,Barros L.,Barreira J.C.M.,Calhelha R.C.,Heleno S.A.,Sayer C.,Miranda C.G.,Leimann F.V.,Barreiro M.F.,Ferreira I.C.F.R.
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)
Food Chemistry, 261, 224-232, 2018

88
Halla N.,Heleno S.A.,Costa P.,Fernandes I.P.,Calhelha R.C.,Boucherit K.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Chemical profile and bioactive properties of the essential oil isolated from Ammodaucus leucotrichus fruits growing in Sahara and its evaluation as a cosmeceutical ingredient
Industrial Crops and Products, 119, 249-254, 2018

89
Francisco C.R.L.,Heleno S.A.,Fernandes I.P.M.,Barreira J.C.M.,Calhelha R.C.,Barros L.,Gonçalves O.H.,Ferreira I.C.F.R.,Barreiro M.F.
Functionalization of yogurts with Agaricus bisporus extracts encapsulated in spray-dried maltodextrin crosslinked with citric acid
Food Chemistry, 245, 845-853, 2018

90
Villavicencio A.L.C.H.,Heleno S.A.,Calhelha R.C.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
The influence of electron beam radiation in the nutritional value, chemical composition and bioactivities of edible flowers of Bauhinia variegata L. var. candida alba Buch.-Ham from Brazil
Food Chemistry, 241, 163-170, 2018

91
Rached W.,Zeghada F.Z.,Bennaceur M.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Carvalho A.M.,Marouf A.,Ferreira I.C.F.R.
Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves
Industrial Crops and Products, 112, 460-466, 2018

92
Halla N.,Fernandes I.P.,Heleno S.A.,Costa P.,Boucherit-Otmani Z.,Boucherit K.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Cosmetics preservation: A review on present strategies
Molecules, 23, , 2018

93
Oludemi T.,Barros L.,Prieto M.A.,Heleno S.A.,Barreiro M.F.,Ferreira I.C.F.R.
Extraction of triterpenoids and phenolic compounds from: Ganoderma lucidum: Optimization study using the response surface methodology
Food and Function, 9, 209-226, 2018

94
Ziani B.E.C.,Barros L.,Boumehira A.Z.,Bachari K.,Heleno S.A.,Alves M.J.,Ferreira I.C.F.R.
Profiling polyphenol composition by HPLC-DAD-ESI/MSn and the antibacterial activity of infusion preparations obtained from four medicinal plants
Food and Function, 9, 149-159, 2018

95
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,González-Paramás A.M.,Barreiro M.F.,Ferreira I.C.F.R.
The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits
Food and Chemical Toxicology, 108, 139-147, 2017

96
Rached W.,Bennaceur M.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Carvalho A.M.,Marouf A.,Ferreira I.C.F.R.
Detailed phytochemical characterization and bioactive properties of: Myrtus nivelii Batt & Trab
Food and Function, 8, 3111-3119, 2017

97
Ferreira I.C.F.R.,Fernandes Â.,Heleno S.A.
Chemical, nutritional, and bioactive potential of mushrooms
Edible and Medicinal Mushrooms: Technology and Applications, 455-501, 2017

98
Svobodova B.,Barros L.,Sopik T.,Calhelha R.C.,Heleno S.,Alves M.J.,Walcott S.,Kuban V.,Ferreira I.C.F.R.
Non-edible parts of Solanum stramoniifolium Jacq.-a new potent source of bioactive extracts rich in phenolic compounds for functional foods
Food and Function, 8, 2013-2021, 2017

99
Svobodova B.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Walcott S.,Bittova M.,Kuban V.,Ferreira I.C.F.R.
Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago
Industrial Crops and Products, 95, 365-373, 2017

100
Heleno S.A.,Rudke A.R.,Calhelha R.C.,Carocho M.,Barros L.,Gonçalves O.H.,Barreiro M.F.,Ferreira I.C.F.R.
Development of dairy beverages functionalized with pure ergosterol and mycosterol extracts: An alternative to phytosterol-based beverages
Food and Function, 8, 103-110, 2017

101
Antonio A.L.,Pereira E.,Pinela J.,Heleno S.,Pereira C.,Ferreira I.C.F.R.
Determination of antioxidant compounds in foodstuff
Food Safety: Innovative Analytical Tools for Safety Assessment, 179-220, 2016

102
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,Barreiro M.F.,González-Paramás A.M.,Ferreira I.C.F.R.
Development of Mushroom-Based cosmeceutical formulations with Anti-Inflammatory, Anti-Tyrosinase, antioxidant, and antibacterial properties
Molecules, 21, , 2016

103
Heleno S.A.,Prieto M.A.,Barros L.,Rodrigues A.,Barreiro M.F.,Ferreira I.C.F.R.
Optimization of microwave-assisted extraction of ergosterol from Agaricus bisporus L. by-products using response surface methodology
Food and Bioproducts Processing, 100, 25-35, 2016

104
Heleno S.A.,Diz P.,Prieto M.A.,Barros L.,Rodrigues A.,Barreiro M.F.,Ferreira I.C.F.R.
Optimization of ultrasound-assisted extraction to obtain mycosterols from Agaricus bisporus L. by response surface methodology and comparison with conventional Soxhlet extraction
Food Chemistry, 197, 1054-1063, 2016

105
Taofiq O.,Calhelha R.C.,Heleno S.,Barros L.,Martins A.,Santos-Buelga C.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives
Food Research International, 76, 821-827, 2015

106
Heleno S.A.,Barros L.,Martins A.,Morales P.,Fernández-Ruiz V.,Glamoclija J.,Sokovic M.,Ferreira I.C.F.R.
Nutritional value, bioactive compounds, antimicrobial activity and bioaccessibility studies with wild edible mushrooms
LWT, 63, 799-806, 2015

107
Heleno S.A.,Ferreira R.C.,Antonio A.L.,Queiroz M.J.R.P.,Barros L.,Ferreira I.C.F.R.
Nutritional value, bioactive compounds and antioxidant properties of three edible mushrooms from Poland
Food Bioscience, 11, 48-55, 2015

108
Heleno S.A.,Barros L.,Martins A.,Queiroz M.J.R.P.,Morales P.,Fernández-Ruiz V.,Ferreira I.C.F.R.
Chemical composition, antioxidant activity and bioaccessibility studies in phenolic extracts of two Hericium wild edible species
LWT, 63, 475-481, 2015

109
Ferreira I.C.F.R.,Heleno S.A.,Reis F.S.,Stojkovic D.,Queiroz M.J.R.P.,Vasconcelos M.H.,Sokovic M.
Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities
Phytochemistry, 114, 38-55, 2015

110
Heleno S.A.,Martins A.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
Food Chemistry, 173, 501-513, 2015

111
Heleno S.A.,Ferreira I.C.F.R.,Ćirić A.,Glamočlija J.,Martins A.,Queiroz M.J.R.P.,Soković M.
Coprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents
Food and Function, 5, 2521-2528, 2014

112
Heleno S.A.,Ferreira I.C.F.R.,Calhelha R.C.,Esteves A.P.,Martins A.,Queiroz M.J.R.P.
Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives
Food Research International, 55, 170-175, 2014

113
Heleno S.A.,Ferreira I.C.F.R.,Esteves A.P.,Ćirić A.,Glamočlija J.,Martins A.,Soković M.,Queiroz M.J.R.P.
Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters
Food and Chemical Toxicology, 58, 95-100, 2013

114
Heleno S.A.,Stojković D.,Barros L.,Glamočlija J.,Soković M.,Martins A.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia
Food Research International, 51, 236-243, 2013

115
Heleno S.A.,Barros L.,Martins A.,Queiroz M.J.R.P.,Santos-Buelga C.,Ferreira I.C.F.R.
Phenolic, polysaccharidic, and lipidic fractions of mushrooms from northeastern portugal: Chemical compounds with antioxidant properties
Journal of Agricultural and Food Chemistry, 60, 4634-4640, 2012

116
Heleno S.A.,Barros L.,Martins A.,Queiroz M.J.R.P.,Santos-Buelga C.,Ferreira I.C.F.R.
Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: A comparative study of the antioxidant potential of phenolic and polysaccharidic extracts
Food Research International, 46, 135-140, 2012

117
Reis F.S.,Heleno S.A.,Barros L.,Sousa M.J.,Martins A.,Santos-Buelga C.,Ferreira I.C.F.R.
Toward the Antioxidant and Chemical Characterization of Mycorrhizal Mushrooms from Northeast Portugal
Journal of Food Science, 76, , 2011

118
Grangeia C.,Heleno S.A.,Barros L.,Martins A.,Ferreira I.C.F.R.
Effects of trophism on nutritional and nutraceutical potential of wild edible mushrooms
Food Research International, 44, 1029-1035, 2011

119
Heleno S.A.,Barros L.,Sousa M.J.,Martins A.,Santos-Buelga C.,Ferreira I.C.F.R.
Targeted metabolites analysis in wild Boletus species
LWT, 44, 1343-1348, 2011

120
Vaz J.A.,Heleno S.A.,Martins A.,Almeida G.M.,Vasconcelos M.H.,Ferreira I.C.F.R.
Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines
Food and Chemical Toxicology, 48, 2881-2884, 2010

121
Heleno S.A.,Barros L.,Sousa M.J.,Martins A.,Ferreira I.C.F.R.
Tocopherols composition of Portuguese wild mushrooms with antioxidant capacity
Food Chemistry, 119, 1443-1450, 2010

122
Barros L.,Heleno S.A.,Carvalho A.M.,Ferreira I.C.F.R.
Lamiaceae often used in Portuguese folk medicine as a source of powerful antioxidants: Vitamins and phenolics
LWT, 43, 544-550, 2010

123
Heleno S.A.,Barros L.,Sousa M.J.,Martins A.,Ferreira I.C.F.R.
Study and characterization of selected nutrients in wild mushrooms from Portugal by gas chromatography and high performance liquid chromatography
Microchemical Journal, 93, 195-199, 2009

124
Barros L.,Heleno S.A.,Carvalho A.M.,Ferreira I.C.F.R.
Systematic evaluation of the antioxidant potential of different parts of Foeniculum vulgare Mill. from Portugal
Food and Chemical Toxicology, 47, 2458-2464, 2009

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