MOUNTAIN
RESEARCH
CENTER

Polytechnic Institute
of Bragança

image01

CIMO

CIMO - Mountain Research Center. See video HERE

FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.

Manuel Ricardo Costa Calhelha

Auxiliary Researcher
Group: Sustainable Processes and Products
Phone: 273330916
E-mail: calhelha@ipb.pt
ORCID: 0000-0002-6801-4578
Scopus Author ID: 6507978333

Career

  • Since 2019: Assistant at CIMO-IPB, Portugal
  • 2017 - 2019: Pos-Doc researcher in the project “Propriedades químicas e bioativas de produtos naturais obtidos a partir de matrizes vegetais e micológicas do Nordeste Transmontano”
  • 2011 - 2016: Pos-doc Researcher (SFRH/BPD/68344/2010)

Qualifications

  • 2010 - in Sciences, specialty in chemistry, University of Minho Minho, Braga, Portugal
  • 2003 - in Biotechnological engineering, Polytechnic Institute of Bragança, Portugal

Interests

  • Antitumor activity of natural extracts (especially mushrooms and aromatic and medicinal plants) using human tumor cell lines
  • Establishment of primary cell cultures from normal cells as toxicity models
  • Anti-inflammatory activity of natural extracts using macrophages
  • Flow cytometry

Projects:

WASTESILK - Silk Sericin as an industrial wastewater with valuable biomedical potential
Funding body: FCT
Reference:
Principal Investigator:Lillian Bouçada de Barros
Start: 2021-01-01
End: 2024-01-01
PreVineGrape - Desenvolvimento de um biofungicida para combate a doenças da videira
Funding body: POCI-FEDER
Reference:
Principal Investigator:Sandrina Alves Heleno
Start: 2021-01-01
End: 2023-06-29
Bio4drinks - Obtenção de Ingredientes Naturais Multifuncionais para a Indústria de Bebidas
Funding body: Programas I&DT Copromoção do Portugal 2020 — Territórios do Interior
Reference:
Principal Investigator:Sandrina Alves Heleno
Start: 2021-09-01
End: 2023-05-30
MAGLIDUO - MAGnetoLIposomes for DUal cancer therapy
Funding body: FCT-SAICT
Reference: POCI-01-0145-FEDER-028020
Principal Investigator:Lillian Bouçada de Barros
Start: 2018-07-01
End: 2021-12-31
IBERPHENOL - Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales
Funding body: POCTEP – Programa de Cooperação Transfronteiriça Portugal – Espanha
Reference:
Principal Investigator:Lillian Bouçada de Barros
Start: 2015-10-01
End: 2020-12-31

Total results: 264
1
Kessler J.C.,Vieira V.,Martins I.M.,Manrique Y.A.,Ferreira P.,Calhelha R.C.,Afonso A.,Barros L.,Rodrigues A.E.,Dias M.M.
The potential of almonds, hazelnuts, and walnuts SFE-CO2 extracts as sources of bread flavouring ingredients
Food Chemistry, 417, , 2023

2
Shiraishi C.S.H.,Zbiss Y.,Roriz C.L.,Dias M.I.,Prieto M.A.,Calhelha R.C.,Alves M.J.,Heleno S.A.,da Cunha Mendes V.,Carocho M.,Abreu R.M.V.,Barros L.
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes, 11, , 2023

3
Leichtweis M.G.,Molina A.K.,Petropoulos S.A.,Carocho M.,Pires T.C.S.P.,Dias M.I.,Calhelha R.,Oliveira M.B.P.P.,Pereira C.,Barros L.
Valorization of Pumpkin Peel as a Source of Bioactive Compounds: Optimization of Heat- and Ultrasound-Assisted Extraction
Molecules, 28, , 2023

4
Dridi A.,Reis F.S.,Pires T.C.S.P.,Calhelha R.C.,Pereira C.,Zaghdoudi K.,Ferreira I.C.F.R.,Barros L.,Barreira J.C.M.
Aesculus hippocastanum L.: A Simple Ornamental Plant or a Source of Compelling Molecules for Industry?
Separations, 10, , 2023

5
Silva B.N.,Cadavez V.,Caleja C.,Pereira E.,Calhelha R.C.,Añibarro-Ortega M.,Finimundy T.,Kostić M.,Soković M.,Teixeira J.A.,Barros L.,Gonzales-Barron U.
Phytochemical Composition and Bioactive Potential of Melissa officinalis L., Salvia officinalis L. and Mentha spicata L. Extracts
Foods, 12, , 2023

6
Albuquerque B.R.,Dias M.I.,Pinela J.,Calhelha R.C.,Pires T.C.S.P.,Alves M.J.,Corrêa R.C.G.,Ferreira I.C.F.R.,Oliveira M.B.P.P.,Barros L.
Insights into the Chemical Composition and In Vitro Bioactive Properties of Mangosteen (Garcinia mangostana L.) Pericarp
Foods, 12, , 2023

7
Albuquerque B.R.,Pinela J.,Dias M.I.,Pereira C.,Petrović J.,Soković M.,Calhelha R.C.,Oliveira M.B.P.P.,Ferreira I.C.F.R.,Barros L.
Valorization of rambutan (Nephelium lappaceum L.) peel: Chemical composition, biological activity, and optimized recovery of anthocyanins
Food Research International, 165, , 2023

8
Madureira J.,Albuquerque B.,Dias M.I.,Pinela J.,Calhelha R.C.,Santos-Buelga C.,Margaça F.M.A.,Ferreira I.C.F.R.,Cabo Verde S.,Barros L.
Ultrasound-assisted extraction of hydroxytyrosol and tyrosol from olive pomace treated by gamma radiation: process optimization and bioactivity assessment
Food and Function, 14, 3038-3050, 2023

9
Calhelha R.C.,Haddad H.,Ribeiro L.,Heleno S.A.,Carocho M.,Barros L.
Inflammation: What’s There and What’s New?
Applied Sciences (Switzerland), 13, , 2023

10
Calheiros D.,Dias M.I.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.,Fernandes C.,Gonçalves T.
Antifungal Activity of Spent Coffee Ground Extracts
Microorganisms, 11, , 2023

11
Kostić M.,Ivanov M.,Fernandes Â.,Calhelha R.C.,Glamočlija J.,Barros L.,Soković M.,Ćirić A.
A Comparative Study of Lactarius Mushrooms: Chemical Characterization, Antibacterial, Antibiofilm, Antioxidant and Cytotoxic Activity
Journal of Fungi, 9, , 2023

12
Aylanc V.,Larbi S.,Calhelha R.,Barros L.,Rezouga F.,Rodríguez-Flores M.S.,Seijo M.C.,El Ghouizi A.,Lyoussi B.,Falcão S.I.,Vilas-Boas M.
Evaluation of Antioxidant and Anticancer Activity of Mono- and Polyfloral Moroccan Bee Pollen by Characterizing Phenolic and Volatile Compounds
Molecules, 28, , 2023

13
Plasencia P.,Heleno S.A.,Finimundy T.,Carocho M.,Calhelha R.C.,Añibarro-Ortega M.,Alves M.J.,Oludemi T.,Quidiongo N.,Barreiro F.,García P.A.,Ferreira I.C.F.R.,Barros L.
Recovery of High Valuable Bioactive Molecules from Vaccinium myrtillus L. Bioresidues
Waste and Biomass Valorization, , 2023

14
Fischer T.E.,Marcondes A.,Zardo D.M.,Nogueira A.,Calhelha R.C.,Vaz J.A.,Barros L.,Zielinski A.A.F.,Alberti A.
Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia
Antioxidants, 11, , 2022

15
Leichtweis M.G.,Molina A.K.,Pires T.C.S.,Dias M.I.,Calhelha R.,Bachari K.,Ziani B.E.C.,Oliveira M.B.P.P.,Pereira C.,Barros L.
Biological Activity of Pumpkin Byproducts: Antimicrobial and Antioxidant Properties
Molecules, 27, , 2022

16
Zaier M.M.,Heleno S.A.,Mandim F.,Calhelha R.C.,Ferreira I.C.F.R.,Achour L.,Kacem A.,Dias M.I.,Barros L.
Effects of the seasonal variation in the phytochemical composition and bioactivities of the wild halophyte Suaeda fruticosa
Food Bioscience, 50, , 2022

17
18
Youssef S.,Custódio L.,Rodrigues M.J.,Pereira C.G.,Calhelha R.C.,Pinela J.,Barros L.,Jekő J.,Cziáky Z.,Ben Hamed K.
Nutritional anti-nutritional chemical composition and antioxidant activities of the leaves of the sea cliff dwelling species Limonium spathulatum (Desf.) Kuntze
Frontiers in Plant Science, 13, , 2022

19
Silva A.S.,Costa E.C.,Reis S.,Spencer C.,Calhelha R.C.,Miguel S.P.,Ribeiro M.P.,Barros L.,Vaz J.A.,Coutinho P.
Silk Sericin: A Promising Sustainable Biomaterial for Biomedical and Pharmaceutical Applications
Polymers, 14, , 2022

20
de la Fuente B.,Pinela J.,Calhelha R.C.,Heleno S.A.,Ferreira I.C.F.R.,Barba F.J.,Berrada H.,Caleja C.,Barros L.
Sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) head oils recovered by microwave-assisted extraction: Nutritional quality and biological properties
Food and Bioproducts Processing, 136, 97-105, 2022

21
Mascoloti Spréa R.,Caleja C.,Pinela J.,Finimundy T.C.,Calhelha R.C.,Kostić M.,Sokovic M.,Prieto M.A.,Pereira E.,Amaral J.S.,Barros L.
Comparative study on the phenolic composition and in vitro bioactivity of medicinal and aromatic plants from the Lamiaceae family
Food Research International, 161, , 2022

22
Garcia-Manieri J.A.A.,Correa V.G.,Corrêa R.C.G.,Dias M.I.,Calhelha R.C.,Ivanov M.,Soković M.,Barros L.,Ferreira I.C.F.R.,Bracht A.,Peralta R.M.
Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems
Biocatalysis and Agricultural Biotechnology, 45, , 2022

23
Polyzos N.,Paschoalinotto B.H.,Compocholi M.,Pinela J.,Heleno S.A.,Calhelha R.C.,Dias M.I.,Barros L.,Petropoulos S.A.
Fertilization of Pot-Grown Cichorium spinosum L.: How It Can Affect Plant Growth, Chemical Profile, and Bioactivities of Edible Parts?
Horticulturae, 8, , 2022

24
Garcia-Oliveira P.,Carreira-Casais A.,Pereira E.,Dias M.I.,Pereira C.,Calhelha R.C.,Stojković D.,Sokovic M.,Simal-Gandara J.,Prieto M.A.,Caleja C.,Barros L.
From Tradition to Health: Chemical and Bioactive Characterization of Five Traditional Plants
Molecules, 27, , 2022

25
da Silva Santos É.,Savam A.,Cabral M.R.P.,Castro J.C.,de Oliveira Collet S.A.,Mandim F.,Calhelha R.C.,Barros L.,da Silva Machado M.d.F.P.,de Oliveira A.J.B.,Gonçalves R.A.C.
Low-cost alternative for the bioproduction of bioactive phenolic compounds of callus cultures from Cereus hildmannianus (K.) Schum
Journal of Biotechnology, 356, 8-18, 2022

26
Moreira B.,Pereira E.,Finimundy T.C.,Pinela J.,Calhelha R.C.,Carocho M.,Stojković D.,Sokovic M.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Pineapple by-products as a source of bioactive compounds with potential for industrial food application
Food and Function, 13, 9959-9972, 2022

27
Vieira D.M.,Pereira C.,Calhelha R.C.,Barros L.,Petrovic J.,Sokovic M.,Barreiro M.F.,Ferreira I.C.F.R.,Castro M.C.R.,Rodrigues P.V.,Machado A.V.
Evaluation of plant extracts as an efficient source of additives for active food packaging
Food Frontiers, 3, 480-488, 2022

28
Nicolescu A.,Babotă M.,Ilea M.,Dias M.I.,Calhelha R.C.,Gavrilaș L.,Rocchetti G.,Crișan G.,Mocan A.,Barros L.,Pârvu A.E.
Potential therapeutic applications of infusions and hydroalcoholic extracts of Romanian glutinous sage (Salvia glutinosa L.)
Frontiers in Pharmacology, 13, , 2022

29
Kessler J.C.,Vieira V.,Martins I.M.,Manrique Y.A.,Ferreira P.,Calhelha R.C.,Afonso A.,Barros L.,Rodrigues A.E.,Dias M.M.
Chemical and organoleptic properties of bread enriched with Rosmarinus officinalis L.: The potential of natural extracts obtained through green extraction methodologies as food ingredients
Food Chemistry, 384, , 2022

30
Mocan A.,Fernandes Â.,Calhelha R.C.,Gavrilaş L.,Ferreira I.C.F.R.,Ivanov M.,Sokovic M.,Barros L.,Babotă M.
Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island
Frontiers in Nutrition, 9, , 2022

31
Alonso-Esteban J.I.,Pinela J.,Ćirić A.,Calhelha R.C.,Soković M.,Ferreira I.C.F.R.,Barros L.,Torija-Isasa E.,Sánchez-Mata M.d.C.
Chemical composition and biological activities of whole and dehulled hemp (Cannabis sativa L.) seeds
Food Chemistry, 374, , 2022

32
Roriz C.L.,Heleno S.A.,Alves M.J.,Oliveira M.B.P.P.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Red pitaya (Hylocereus costaricensis) peel as a source of valuable molecules: Extraction optimization to recover natural colouring agents
Food Chemistry, 372, , 2022

33
Silva A.R.,Ayuso M.,Pereira C.,Dias M.I.,Kostić M.,Calhelha R.C.,Soković M.,García P.A.,Ferreira I.C.F.R.,Barros L.
Evaluation of parasite and host phenolic composition and bioactivities − The Practical Case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter
Industrial Crops and Products, 176, , 2022

34
Kostić M.,Ivanov M.,Markovic T.,Sanković Babić S.,Barros L.,Calhelha R.,Sokovic M.,Ciric A.
An in vitro study of the origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: antibacterial, antibiofilm, antioxidant, and cytotoxic activities
Journal of Essential Oil Research, 34, 533-543, 2022

35
Derbassi N.,C. Pedrosa M.,Heleno S.,Fernandes F.,Dias M.I.,Calhelha R.C.,Rodrigues P.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Arbutus unedo leaf extracts as potential dairy preservatives: case study on quark cheese
Food and Function, , 2022

36
Bortolucci W.d.C.,Raimundo K.F.,Fernandez C.M.M.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.,Gonçalves J.E.,Linde G.A.,Colauto N.B.,Gazim Z.C.
Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil
Natural Product Research, 36, 2878-2883, 2022

37
Nikolić M.,Marković T.,Marković D.,Calhelha R.C.,Fernandes Â.,Ferreira I.C.F.R.,Stojković D.,Ćirić A.,Glamočlija J.,Soković M.
Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute
Journal of the Serbian Chemical Society, 86, 1291-1303, 2021

38
Tedjini R.,Ziani B.E.C.,Casimiro T.,Viveiros R.,Calhelha R.C.,Barros L.,Boukenna L.,Hamdi A.,Chebout R.,Bachari K.,Talhi O.,Silva A.M.S.
Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)
Journal of Molecular Structure, 1246, , 2021

39
Mehdi I.E.,Falcão S.I.,Harandou M.,Boujraf S.,Calhelha R.C.,Ferreira I.C.F.R.,Anjos O.,Campos M.G.,Vilas-Boas M.
Chemical, cytotoxic, and anti-inflammatory assessment of honey bee venom from apis mellifera intermissa
Antibiotics, 10, , 2021

40
Xavier V.,Finimundy T.C.,Heleno S.A.,Amaral J.S.,Calhelha R.C.,Vaz J.,Pires T.C.S.P.,Mediavilla I.,Esteban L.S.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive characterization of the essential oils obtained from three mediterranean plants
Molecules, 26, , 2021

41
Sampaio S.L.,Petropoulos S.A.,Dias M.I.,Pereira C.,Calhelha R.C.,Fernandes Â.,Leme C.M.M.,Alexopoulos A.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.
Phenolic composition and cell-based biological activities of ten coloured potato peels (Solanum tuberosum L.)
Food Chemistry, 363, , 2021

42
Rio I.S.R.,Rodrigues A.R.O.,Rodrigues J.M.,Queiroz M.J.R.P.,Calhelha R.C.,Ferreira I.C.F.R.,Almeida B.G.,Pires A.,Pereira A.M.,Araújo J.P.,Castanheira E.M.S.,Coutinho P.J.G.
Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapy
Pharmaceutics, 13, , 2021

43
Añibarro-Ortega M.,Pinela J.,Ćirić A.,Lopes E.,Molina A.K.,Calhelha R.C.,Soković M.,Ferreira O.,Ferreira I.C.F.R.,Barros L.
Extraction of aloesin from aloe vera rind using alternative green solvents: Process optimization and biological activity assessment
Biology, 10, , 2021

44
Pires E.d.O.,Pereira E.,Carocho M.,Pereira C.,Dias M.I.,Calhelha R.C.,Ćirić A.,Soković M.,Garcia C.C.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Study on the potential application of impatiens balsamina l. Flowers extract as a natural colouring ingredient in a pastry product
International Journal of Environmental Research and Public Health, 18, , 2021

45
46
Giordano M.,Pinela J.,Dias M.I.,Calhelha R.C.,Stojković D.,Soković M.,Tavares D.,Cánepa A.L.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Ultrasound-assisted extraction of flavonoids from kiwi peel: Process optimization and bioactivity assessment
Applied Sciences (Switzerland), 11, , 2021

47
Petropoulos S.A.,Fernandes Â.,Calhelha R.C.,Rouphael Y.,Petrović J.,Soković M.,Ferreira I.C.F.R.,Barros L.
Antimicrobial properties, cytotoxic effects, and fatty acids composition of vegetable oils from purslane, linseed, luffa, and pumpkin seeds
Applied Sciences (Switzerland), 11, , 2021

48
Alaya I.B.,Pereira E.,Dias M.I.,Pinela J.,Calhelha R.C.,Soković M.,Kostić M.,Prieto M.A.,Essid F.,Caleja C.,Ferreira I.C.F.R.,Barros L.
Development of a natural preservative from chestnut flowers: Ultrasound-assisted extraction optimization and functionality assessment
Chemosensors, 9, , 2021

49
Ceccanti C.,Finimundy T.C.,Heleno S.A.,Pires T.C.S.P.,Calhelha R.C.,Guidi L.,Ferreira I.C.F.R.,Barros L.
Differences in the phenolic composition and nutraceutical properties of freeze dried and oven-dried wild and domesticated samples of Sanguisorba minor Scop
LWT, 145, , 2021

50
Roriz C.L.,Xavier V.,Heleno S.A.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive features of amaranthus caudatus l. Flowers and optimized ultrasound-assisted extraction of betalains
Foods, 10, , 2021

51
Rodrigues J.P.B.,Fernandes Â.,Dias M.I.,Pereira C.,Pires T.C.S.P.,Calhelha R.C.,Carvalho A.M.,Ferreira I.C.F.R.,Barros L.
Phenolic compounds and bioactive properties of Ruscus aculeatus L. (asparagaceae): The pharmacological potential of an underexploited subshrub
Molecules, 26, , 2021

52
Albuquerque B.R.,Dias M.I.,Pereira C.,Petrović J.,Soković M.,Calhelha R.C.,Oliveira M.B.P.P.,Ferreira I.C.F.R.,Barros L.
Valorization of sicana odorifera (Vell.) naudin epicarp as a source of bioactive compounds: Chemical characterization and evaluation of its bioactive properties
Foods, 10, , 2021

53
García-Pérez P.,Ayuso M.,Lozano-Milo E.,Pereira C.,Dias M.I.,Ivanov M.,Calhelha R.C.,Soković M.,Ferreira I.C.F.R.,Barros L.,Gallego P.P.
Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants
Industrial Crops and Products, 162, , 2021

54
Fernandes Â.,Bancessi A.,Pinela J.,Dias M.I.,Liberal Â.,Calhelha R.C.,Ćirić A.,Soković M.,Catarino L.,Ferreira I.C.F.R.,Barros L.
Nutritional and phytochemical profiles and biological activities of Moringa oleifera Lam. edible parts from Guinea-Bissau (West Africa)
Food Chemistry, 341, , 2021

55
Novais C.,Pereira C.,Molina A.K.,Liberal Â.,Dias M.I.,Añibarro-Ortega M.,Alves M.J.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.
Bioactive and nutritional potential of medicinal and aromatic plant (Map) seasoning mixtures
Molecules, 26, , 2021

56
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.C.,Ivanov M.,Sokovic M.D.,Ferreira I.C.F.R.,Barros L.
Effects of growing substrate and nitrogen fertilization on the chemical composition and bioactive properties of centaurea raphanina Ssp. Mixta (dc.) Runemark
Agronomy, 11, , 2021

57
Ueda J.M.,Pedrosa M.C.,Fernandes F.A.,Rodrigues P.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.A.,Carocho M.,Ineu R.P.,Ferreira I.C.F.R.,Barros L.
Promising preserving agents from sage and basil: A case study with yogurts
Foods, 10, , 2021

58
Paschoalinotto B.H.,Dias M.I.,Pinela J.,Pires T.C.S.P.,Alves M.J.,Mocan A.,Calhelha R.C.,Barros L.,Ineu R.P.,Ferreira I.C.F.R.
Phytochemical characterization and evaluation of bioactive properties of tisanes prepared from promising medicinal and aromatic plants
Foods, 10, 1-26, 2021

59
Tejedor-Calvo E.,Amara K.,Reis F.S.,Barros L.,Martins A.,Calhelha R.C.,Venturini M.E.,Blanco D.,Redondo D.,Marco P.,Ferreira I.C.F.R.
Chemical composition and evaluation of antioxidant, antimicrobial and antiproliferative activities of Tuber and Terfezia truffles
Food Research International, 140, , 2021

60
Ribeiro A.S.,Costa S.M.,Ferreira D.P.,Calhelha R.C.,Barros L.,Stojković D.,Soković M.,Ferreira I.C.F.R.,Fangueiro R.
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
Reactive and Functional Polymers, 159, , 2021

61
Gómez-Mejía E.,Roriz C.L.,Heleno S.A.,Calhelha R.,Dias M.I.,Pinela J.,Rosales-Conrado N.,León-González M.E.,Ferreira I.C.F.R.,Barros L.
Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential
Food Chemistry, 337, , 2021

62
Ivanov M.,Kannan A.,Stojković D.S.,Glamočlija J.,Calhelha R.C.,Ferreira I.C.F.R.,Sanglard D.,Soković M.
Camphor and eucalyptol—anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity
International Journal of Molecular Sciences, 22, 1-14, 2021

63
Pires E.d.O.,Pereira E.,Pereira C.,Dias M.I.,Calhelha R.C.,Ćirić A.,Soković M.,Hassemer G.,Garcia C.C.,Caleja C.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive characterisation of Impatiens walleriana
Molecules, 26, , 2021

64
Pedrosa M.C.,Ueda J.M.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.,da Silva A.B.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Preservation of chocolate muffins with Lemon Balm, Oregano, and Rosemary extracts
Foods, 10, , 2021

65
Ivanov M.,Kannan A.,Stojković D.S.,Glamočlija J.,Calhelha R.C.,Ferreira I.C.F.R.,Sanglard D.,Soković M.
Flavones, flavonols, and glycosylated derivatives—impact on candida albicans growth and virulence, expression of cdr1 and erg11, cytotoxicity
Pharmaceuticals, 14, 1-12, 2021

66
Pantuzza Silva G.F.,Pereira E.,Melgar B.,Stojković D.,Sokovic M.,Calhelha R.C.,Pereira C.,Abreu R.M.V.,Ferreira I.C.F.R.,Barros L.
Eggplant fruit (Solanum melongena l.) and bio‐residues as a source of nutrients, bioactive compounds, and food colorants, using innovative food technologies
Applied Sciences (Switzerland), 11, 1-24, 2021

67
Pires T.C.S.P.,Inês Dias M.,Calhelha R.C.,José Alves M.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.
Development of new bilberry (Vaccinium myrtillus L.) based snacks: Nutritional, chemical and bioactive features
Food Chemistry, 334, , 2021

68
Pereira E.,Cadavez V.,Barros L.,Encina-Zelada C.,Stojković D.,Sokovic M.,Calhelha R.C.,Gonzales-Barron U.,Ferreira I.C.F.R.
Chenopodium quinoa Willd. (quinoa) grains: A good source of phenolic compounds
Food Research International, 137, , 2020

69
Finimundy T.C.,Karkanis A.,Fernandes Â.,Petropoulos S.A.,Calhelha R.,Petrović J.,Soković M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes
Food Chemistry, 327, , 2020

70
Petropoulos S.A.,Fernandes Â.,Plexida S.,Pereira C.,Dias M.I.,Calhelha R.,Chrysargyris A.,Tzortzakis N.,Petrović J.,Soković M.D.,Ferreira I.C.F.R.,Barros L.
The sustainable use of cotton, hazelnut and ground peanut waste in vegetable crop production
Sustainability (Switzerland), 12, 1-17, 2020

71
Kostić M.,Ivanov M.,Fernandes Â.,Pinela J.,Calhelha R.C.,Glamočlija J.,Barros L.,Ferreira I.C.F.R.,Soković M.,Ćirić A.
Antioxidant extracts of three russula genus species express diverse biological activity
Molecules, 25, , 2020

72
Ziani B.E.C.,Carocho M.,Abreu R.M.V.,Bachari K.,Alves M.J.,Calhelha R.C.,Talhi O.,Barros L.,Ferreira I.C.F.R.
Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts
Food Bioscience, 36, , 2020

73
Madureira J.,Dias M.I.,Pinela J.,Calhelha R.C.,Barros L.,Santos-Buelga C.,Margaça F.M.A.,Ferreira I.C.F.R.,Cabo Verde S.
The use of gamma radiation for extractability improvement of bioactive compounds in olive oil wastes
Science of the Total Environment, 727, , 2020

74
Spréa R.M.,Fernandes Â.,Finimundy T.C.,Pereira C.,Alves M.J.,Calhelha R.C.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Lovage (Levisticum officinale W.D.J. Koch) roots: A source of bioactive compounds towards a circular economy
Resources, 9, , 2020

75
Ghada B.,Pereira E.,Pinela J.,Prieto M.A.,Pereira C.,Calhelha R.C.,Stojkovic D.,Sokóvic M.,Zaghdoudi K.,Barros L.,Ferreira I.C.F.R.
Recovery of anthocyanins from passion fruit epicarp for food colorants: Extraction process optimization and evaluation of bioactive properties
Molecules, 25, , 2020

76
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelh R.C.,Ivanov M.,Sokovi M.D.,Ferreira I.C.F.R.,Barros L.
The effect of nitrogen fertigation and harvesting time on plant growth and chemical composition of centaurea raphanina subsp. mixta (DC.) Runemark
Molecules, 25, , 2020

77
Coelho J.,Barros L.,Dias M.I.,Finimundy T.C.,Amaral J.S.,Alves M.J.,Calhelha R.C.,Santos P.F.,Ferreira I.C.F.R.
Echinacea purpurea (L.) moench: Chemical characterization and bioactivity of its extracts and fractions
Pharmaceuticals, 13, 1-16, 2020

78
Vieira V.,Calhelha R.C.,Barros L.,Coutinho J.A.P.,Ferreira I.C.F.R.,Ferreira O.
Insights on the extraction performance of alkanediols and glycerol: Using Juglans regia L. Leaves as a source of bioactive compounds
Molecules, 25, , 2020

79
Ayuso M.,Pinela J.,Dias M.I.,Barros L.,Ivanov M.,Calhelha R.C.,Soković M.,Ramil-Rego P.,Barreal M.E.,Gallego P.P.,Ferreira I.C.F.R.
Phenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gay
Industrial Crops and Products, 148, , 2020

80
Pinela J.,Omarini A.B.,Stojković D.,Barros L.,Postemsky P.D.,Calhelha R.C.,Breccia J.,Fernández-Lahore M.,Soković M.,Ferreira I.C.F.R.
Biotransformation of rice and sunflower side-streams by dikaryotic and monokaryotic strains of Pleurotus sapidus: Impact on phenolic profiles and bioactive properties
Food Research International, 132, , 2020

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82
Gonzales-Barron U.,Dijkshoorn R.,Maloncy M.,Finimundy T.,Calhelha R.C.,Pereira C.,Stojković D.,Soković M.,Ferreira I.C.F.R.,Barros L.,Cadavez V.
Nutritive and bioactive properties of mesquite (prosopis pallida) flour and its technological performance in breadmaking
Foods, 9, , 2020

83
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.C.,Chrysargyris A.,Tzortzakis N.,Ivanov M.,Sokovic M.D.,Barros L.,Ferreira I.C.F.R.
Chemical composition and plant growth of Centaurea raphanina subsp. mixta plants cultivated under saline conditions
Molecules, 25, , 2020

84
Finimundy T.C.,Pereira C.,Dias M.I.,Caleja C.,Calhelha R.C.,Sokovic M.,Stojković D.,Carvalho A.M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Infusions of herbal blends as promising sources of phenolic compounds and bioactive properties
Molecules, 25, , 2020

85
Majdi C.,Pereira C.,Dias M.I.,Calhelha R.C.,Alves M.J.,Frih B.,Charrouf Z.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Phytochemical characterization and bioactive properties of cinnamon basil (Ocimum basilicum cv. ‘cinnamon’) and lemon basil (ocimum x citriodorum)
Antioxidants, 9, , 2020

86
Sampaio S.L.,Fernandes Â.,Pereira C.,Calhelha R.C.,Sokovic M.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
Nutritional value, physicochemical characterization and bioactive properties of the Brazilian quinoa: BRS Piabiru
Food and Function, 11, 2969-2977, 2020

87
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.,Di Gioia F.,Tzortzakis N.,Ivanov M.,Sokovic M.,Barros L.,Ferreira I.C.F.R.
Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds
Antioxidants, 9, , 2020

88
Albuquerque B.R.,Pereira C.,Calhelha R.C.,José Alves M.,Abreu R.M.V.,Barros L.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties
Food Chemistry, 309, , 2020

89
Caleja C.,Barros L.,Barreira J.C.M.,Soković M.,Calhelha R.C.,Bento A.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Castanea sativa male flower extracts as an alternative additive in the Portuguese pastry delicacy "pastel de nata"
Food and Function, 11, 2208-2217, 2020

90
Vieira V.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Coutinho J.A.P.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals
Food and Chemical Toxicology, 137, , 2020

91
Spréa R.M.,Fernandes Â.,Calhelha R.C.,Pereira C.,Pires T.C.S.P.,Alves M.J.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Chemical and bioactive characterization of the aromatic plant: Levisticum officinale W.D.J. Koch: a comprehensive study
Food and Function, 11, 1292-1303, 2020

92
Silva A.R.,Pinela J.,Dias M.I.,Calhelha R.C.,Alves M.J.,Mocan A.,García P.A.,Barros L.,Ferreira I.C.F.R.
Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties
Food and Chemical Toxicology, 136, , 2020

93
Lageiro M.M.,Castanho A.,Pereira C.,Calhelha R.C.,Ferreira I.C.F.R.,Brites C.
Assessment of gamma oryzanol variability, an attractive rice bran bioactive compound
Emirates Journal of Food and Agriculture, 32, 38-46, 2020

94
da Silva Veloso F.,Caleja C.,Calhelha R.C.,Pires T.C.S.,Alves M.J.,Barros L.,Genena A.K.,Barreira J.C.M.,Ferreira I.C.F.R.
Characterization and application of pomegranate epicarp extracts as functional ingredients in a typical Brazilian pastry product
Molecules, 25, , 2020

95
Conceição N.,Albuquerque B.R.,Pereira C.,Corrêa R.C.G.,Lopes C.B.,Calhelha R.C.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
By-products of camu-camu [Myrciaria dubia (Kunth) McVaugh] as promising sources of bioactive high added-value food ingredients: Functionalization of yogurts
Molecules, 25, , 2020

96
Dias M.,Caleja C.,Pereira C.,Calhelha R.C.,Kostic M.,Sokovic M.,Tavares D.,Baraldi I.J.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive properties of byproducts from two different kiwi varieties
Food Research International, 127, , 2020

97
Ferreira L.F.V.,Machado I.F.,Gama A.,Socoteanu R.P.,Boscencu R.,Manda G.,Calhelha R.C.,Ferreira I.C.F.R.
Photochemical /photocytotoxicity studies of new tetrapyrrolic structures as potential candidates for cancer theranostics
Current Drug Discovery Technologies, 17, 661-669, 2020

98
Graça V.C.,Calhelha R.C.,Nunes F.M.,Berthet J.,Ferreira I.C.F.R.,Santos P.F.
Isolation of secondary metabolites from Geranium molle L. with anticancer potential
Industrial Crops and Products, 142, , 2019

99
Pereira C.,Dias M.I.,Petropoulos S.A.,Plexida S.,Chrysargyris A.,Tzortzakis N.,Calhelha R.C.,Ivanov M.,Stojković D.,Soković M.,Barros L.,Ferreira I.C.F.R.
The effects of biostimulants, biofertilizers and water-stress on nutritional value and chemical composition of two spinach genotypes (Spinacia oleracea L.)
Molecules, 24, , 2019

100
Ćirić A.,Kruljević I.,Stojković D.,Fernandes Â.,Barros L.,Calhelha R.C.,Ferreira I.C.F.R.,Soković M.,Glamočlija J.
Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: Functional foods with diverse biological activities
Food and Function, 10, 7678-7686, 2019

101
Chihoub W.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Valorisation of the green waste parts from turnip, radish and wild cardoon: Nutritional value, phenolic profile and bioactivity evaluation
Food Research International, 126, , 2019

102
Petropoulos S.A.,Fernandes Â.,Calhelha R.C.,Di Gioia F.,Kolovou P.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive properties of Cichorium spinosum L. in relation to nitrate/ammonium nitrogen ratio
Journal of the Science of Food and Agriculture, 99, 6741-6750, 2019

103
Afonso A.F.,Pereira O.R.,Fernandes Â.,Calhelha R.C.,Silva A.M.S.,Ferreira R.C.F.,Cardoso S.M.
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts
Molecules, 24, , 2019

104
Campestrini L.H.,Melo P.S.,Peres L.E.P.,Calhelha R.C.,Ferreira I.C.F.R.,Alencar S.M.
A new variety of purple tomato as a rich source of bioactive carotenoids and its potential health benefits
Heliyon, 5, , 2019

105
Harumi Iyda J.,Fernandes Â.,Calhelha R.C.,Alves M.J.,Ferreira F.D.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Nutritional composition and bioactivity of Umbilicus rupestris (Salisb.)Dandy: An underexploited edible wild plant
Food Chemistry, 295, 341-349, 2019

106
Añibarro-Ortega M.,Pinela J.,Barros L.,Ćirić A.,Silva S.P.,Coelho E.,Mocan A.,Calhelha R.C.,Soković M.,Coimbra M.A.,Ferreira I.C.F.R.
Compositional features and bioactive properties of aloe vera leaf (Fillet, mucilage, and rind) and flower
Antioxidants, 8, , 2019

107
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest
Food Chemistry, 294, 302-308, 2019

108
Arribas C.,Pereira E.,Barros L.,Alves M.J.,Calhelha R.C.,Guillamón E.,Pedrosa M.M.,Ferreira I.C.F.R.
Healthy novel gluten-free formulations based on beans, carob fruit and rice: Extrusion effect on organic acids, tocopherols, phenolic compounds and bioactivity
Food Chemistry, 292, 304-313, 2019

109
Pereira D.S.M.,Cardoso B.D.,Rodrigues A.R.O.,Amorim C.O.,Amaral V.S.,Almeida B.G.,Queiroz M.J.R.P.,Martinho O.,Baltazar F.,Calhelha R.C.,Ferreira I.C.F.R.,Coutinho P.J.G.,Castanheira E.M.S.
Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
Pharmaceutics, 11, , 2019

110
Caleja C.,Finimundy T.C.,Pereira C.,Barros L.,Calhelha R.C.,Sokovic M.,Ivanov M.,Carvalho A.M.,Rosa E.,Ferreira I.C.F.R.
Challenges of traditional herbal teas: Plant infusions and their mixtures with bioactive properties
Food and Function, 10, 5939-5951, 2019

111
Rached W.,Barros L.,Ziani B.E.C.,Bennaceur M.,Calhelha R.C.,Heleno S.A.,Alves M.J.,Marouf A.,Ferreira I.C.F.R.
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.
Food and Function, 10, 5898-5909, 2019

112
da Silva S.C.,Fernandes I.P.,Barros L.,Fernandes Â.,José Alves M.,Calhelha R.C.,Pereira C.,Barreira J.C.M.,Manrique Y.,Colla E.,Ferreira I.C.F.R.,Filomena Barreiro M.
Spray-dried Spirulina platensis as an effective ingredient to improve yogurt formulations: Testing different encapsulating solutions
Journal of Functional Foods, 60, , 2019

113
Afonso A.F.,Pereira O.R.,Fernandes Â.S.F.,Calhelha R.C.,Silva A.M.S.,Ferreira I.C.F.R.,Cardoso S.M.
The health-benefits and phytochemical profile of salvia apiana and salvia farinacea var. Victoria blue decoctions
Antioxidants, 8, , 2019

114
Falcão S.I.,Calhelha R.C.,Touzani S.,Lyoussi B.,Ferreira I.C.F.R.,Vilas-Boas M.
In vitro interactions of moroccan propolis phytochemical’s on human tumor cell lines and anti-inflammatory properties
Biomolecules, 9, , 2019

115
Vieira V.,Pereira C.,Pires T.C.S.P.,Calhelha R.C.,Alves M.J.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal
Industrial Crops and Products, 134, 347-355, 2019

116
Alonso-Esteban J.I.,Pinela J.,Barros L.,Ćirić A.,Soković M.,Calhelha R.C.,Torija-Isasa E.,de Cortes Sánchez-Mata M.,Ferreira I.C.F.R.
Phenolic composition and antioxidant, antimicrobial and cytotoxic properties of hop (Humulus lupulus L.) Seeds
Industrial Crops and Products, 134, 154-159, 2019

117
Da Silva L.,Pereira E.,Prieto M.,Simal-Gandara J.,Pires T.,Alves M.,Calhelha R.,Barros L.,Ferreira I.
Rubus ulmifolius Schott as a Novel Source of Food Colorant: Extraction optimization of coloring pigments and incorporation in a bakery product
Molecules, 24, , 2019

118
Fernandes F.,Pereira E.,Círić A.,Soković M.,Calhelha R.,Barros L.,Ferreira I.
Ocimum basilicum var. Purpurascens leaves (red rubin basil): A source of bioactive compounds and natural pigments for the food industry
Food and Function, 10, 3161-3171, 2019

119
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity
Microchemical Journal, 147, 469-477, 2019

120
Castanho A.,Lageiro M.,Calhelha R.C.,Ferreira I.C.F.R.,Sokovic M.,Cunha L.M.,Brites C.
Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties
Food and Function, 10, 2382-2389, 2019

121
Chahdoura H.,Barreira J.C.M.,Barros L.,Dias M.I.,Calhelha R.C.,Flamini G.,Soković M.,Achour L.,Ferreira I.C.F.R.
Bioactivity, hydrophilic, lipophilic and volatile compounds in pulps and skins of Opuntia macrorhiza and Opuntia microdasys fruits
LWT, 105, 57-65, 2019

122
Jabeur I.,Pereira E.,Caleja C.,Calhelha R.C.,Soković M.,Catarino L.,Barros L.,Ferreira I.C.F.R.
Exploring the chemical and bioactive properties of: Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa)
Food and Function, 10, 2234-2243, 2019

123
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds
Journal of Functional Foods, 55, 325-332, 2019

124
Pinho E.,Calhelha R.C.,Ferreira I.C.F.R.,Soares G.
Cotton-hydrogel composite for improved wound healing: Antimicrobial activity and anti-inflammatory evaluation—Part 2
Polymers for Advanced Technologies, 30, 863-871, 2019

125
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Amantagula Fruit (Carissa macrocarpa (Eckl.) A.DC.): Nutritional and Phytochemical Characterization
Plant Foods for Human Nutrition, 74, 76-82, 2019

126
Silva de Sá I.,Peron A.P.,Leimann F.V.,Bressan G.N.,Krum B.N.,Fachinetto R.,Pinela J.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Gonçalves O.H.,Ineu R.P.
In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions
Food and Chemical Toxicology, 125, 29-37, 2019

127
López C.J.,Caleja C.,Prieto M.A.,Sokovic M.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes
Food Chemistry, 275, 426-438, 2019

128
Fernandes F.,Pereira E.,Prieto M.,Calhelha R.,Ćirić A.,Soković M.,Simal-Gandara J.,Barros L.,Ferreira I.
Optimization of the Extraction Process to Obtain a Colorant Ingredient from Leaves of Ocimum basilicum var. Purpurascens
Molecules, 24, , 2019

129
Dos Santos P.D.F.,Francisco C.R.L.,Coqueiro A.,Leimann F.V.,Pinela J.,Calhelha R.C.,Porto Ineu R.,Ferreira I.C.F.R.,Bona E.,Gonçalves O.H.
The nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Food and Function, 10, 573-582, 2019

130
Ziani B.E.C.,Rached W.,Bachari K.,Alves M.J.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck
Journal of Functional Foods, 53, 237-247, 2019

131
Lockowandt L.,Pinela J.,Roriz C.,Pereira C.,Abreu R.,Calhelha R.,Alves M.,Barros L.,Bredol M.,Ferreira I.
Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part
Industrial Crops and Products, 128, 496-503, 2019

132
Gonçalves G.A.,Corrêa R.C.G.,Barros L.,Dias M.I.,Calhelha R.C.,Correa V.G.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid
Food Chemistry, 271, 393-400, 2019

133
Da Silva R.,Barreira J.,Heleno S.,Barros L.,Calhelha R.,Ferreira I.
Anthocyanin profile of elderberry juice: A natural-based bioactive colouring ingredient with potential food application
Molecules, 24, , 2019

134
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers
Molecules, 24, , 2019

135
Mandim F.,Graça V.C.,Calhelha R.C.,Machado I.L.F.,Ferreira L.F.V.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of new iodinated aminosquaraines as potential sensitizers for photodynamic therapy
Molecules, 24, , 2019

136
Magalhães Á.F.,Graça V.C.,Calhelha R.C.,Ferreira Machado I.L.,Vieira Ferreira L.F.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines
Photochemical and Photobiological Sciences, 18, 336-342, 2019

137
Mandim F.,Barros L.,Calhelha R.,Abreu R.,Pinela J.,Alves M.,Heleno S.,Santos P.,Ferreira I.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

138
Rodrigues R.O.,Baldi G.,Doumett S.,Garcia-Hevia L.,Gallo J.,Bañobre-López M.,Dražić G.,Calhelha R.C.,Ferreira I.C.F.R.,Lima R.,Gomes H.T.,Silva A.M.T.
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery
Materials Science and Engineering C, 93, 206-217, 2018

139
Petropoulos S.,Fernandes Â.,Calhelha R.,Danalatos N.,Barros L.,Ferreira I.
How extraction method affects yield, fatty acids composition and bioactive properties of cardoon seed oil?
Industrial Crops and Products, 124, 459-465, 2018

140
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile
Industrial Crops and Products, 124, 44-52, 2018

141
Zan R.A.,Fernandes Â.,Jedoz S.,Oludemi T.,Calhelha R.C.,Pires T.C.S.P.,Alves M.J.,Martins R.C.C.,Barros L.,Ferreira I.C.F.R.
Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
Food and Function, 9, 5621-5628, 2018

142
Pires T.,Dias M.,Barros L.,Calhelha R.,Alves M.,Santos-Buelga C.,Ferreira I.
Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits
Industrial Crops and Products, 122, 574-581, 2018

143
Pereira E.,Pimenta A.I.,Barros L.,Calhelha R.C.,Antonio A.L.,Cabo Verde S.,Ferreira I.C.F.R.
Effects of gamma radiation on the bioactivity of medicinal and aromatic plants: Mentha × piperita L., Thymus vulgaris L. and Aloysia citrodora Paláu as case studies
Food and Function, 9, 5150-5161, 2018

144
Almeida H.H.S.,Barros L.,Barreira J.C.M.,Calhelha R.C.,Heleno S.A.,Sayer C.,Miranda C.G.,Leimann F.V.,Barreiro M.F.,Ferreira I.C.F.R.
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)
Food Chemistry, 261, 224-232, 2018

145
Ghouti D.,Rached W.,Abdallah M.,Pires T.C.S.P.,Calhelha R.C.,Alves M.J.,Abderrahmane L.H.,Barros L.,Ferreira I.C.F.R.
Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria
Food and Function, 9, 4664-4672, 2018

146
Santos K.S.,Barbosa A.M.,Freitas V.,Muniz A.V.C.S.,Mendonça M.C.,Calhelha R.C.,Ferreira I.C.F.R.,Franceschi E.,Padilha F.F.,Oliveira M.B.P.P.,Dariva C.
Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction
Pharmaceuticals, 11, , 2018

147
Halla N.,Heleno S.A.,Costa P.,Fernandes I.P.,Calhelha R.C.,Boucherit K.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Chemical profile and bioactive properties of the essential oil isolated from Ammodaucus leucotrichus fruits growing in Sahara and its evaluation as a cosmeceutical ingredient
Industrial Crops and Products, 119, 249-254, 2018

148
Nenadić M.,Soković M.,Calhelha R.,Ferreira I.,Ćirić A.,Vesović N.,Ćurčić S.
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
Biologia, 73, 787-792, 2018

149
Kungel P.T.A.N.,Correa V.G.,Corrêa R.C.G.,Peralta R.A.,Soković M.,Calhelha R.C.,Bracht A.,Ferreira I.C.F.R.,Peralta R.M.
Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)
International Journal of Biological Macromolecules, 114, 1161-1167, 2018

150
Rocha F.,Yumi Sugahara L.,Leimann F.V.,De Oliveira S.M.,Da Silva Brum E.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Porto Ineu R.,Gonçalves O.H.
Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties
Food and Function, 9, 3698-3706, 2018

151
Peixoto C.M.,Dias M.I.,Alves M.J.,Calhelha R.C.,Barros L.,Pinho S.P.,Ferreira I.C.F.R.
Grape pomace as a source of phenolic compounds and diverse bioactive properties
Food Chemistry, 253, 132-138, 2018

152
Caleja C.,Barros L.,Barreira J.C.M.,Ciric A.,Sokovic M.,Calhelha R.C.,Beatriz M.,Oliveira P.P.,Ferreira I.C.F.R.
Suitability of lemon balm (Melissa officinalis L.) extract rich in rosmarinic acid as a potential enhancer of functional properties in cupcakes
Food Chemistry, 250, 67-74, 2018

153
Francisco C.R.L.,Heleno S.A.,Fernandes I.P.M.,Barreira J.C.M.,Calhelha R.C.,Barros L.,Gonçalves O.H.,Ferreira I.C.F.R.,Barreiro M.F.
Functionalization of yogurts with Agaricus bisporus extracts encapsulated in spray-dried maltodextrin crosslinked with citric acid
Food Chemistry, 245, 845-853, 2018

154
Finimundy T.C.,Barros L.,Calhelha R.C.,Alves M.J.,Prieto M.A.,Abreu R.M.V.,Dillon A.J.P.,Henriques J.A.P.,Roesch-Ely M.,Ferreira I.C.F.R.
Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds
Food Chemistry, 245, 150-158, 2018

155
Graça V.C.,Dias M.I.,Barros L.,Calhelha R.C.,Santos P.F.,Ferreira I.C.F.R.
Fractionation of the more active extracts of: Geranium molle L.: A relationship between their phenolic profile and biological activity
Food and Function, 9, 2032-2042, 2018

156
Adouni K.,Chahdoura H.,Mosbah H.,Santos-Buelga C.,González-Paramás A.M.,Ciudad-Mulero M.,Fernandes Â.,Calhelha R.C.,Morales P.,Flamini G.,Ferreira I.C.F.R.,Achour L.
Revalorization of wild: Asparagus stipularis Forssk. as a traditional vegetable with nutritional and functional properties
Food and Function, 9, 1578-1586, 2018

157
Pires T.C.S.P.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Oliveira M.B.P.P.,Santos-Buelga C.,Ferreira I.C.F.R.
Edible flowers as sources of phenolic compounds with bioactive potential
Food Research International, 105, 580-588, 2018

158
Petrova K.T.,Barros M.T.,Calhelha R.C.,Soković M.,Ferreira I.C.F.R.
Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
Medicinal Chemistry Research, 27, 980-988, 2018

159
Villavicencio A.L.C.H.,Heleno S.A.,Calhelha R.C.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
The influence of electron beam radiation in the nutritional value, chemical composition and bioactivities of edible flowers of Bauhinia variegata L. var. candida alba Buch.-Ham from Brazil
Food Chemistry, 241, 163-170, 2018

160
Smiljkovic M.,Matsoukas M.T.,Kritsi E.,Zelenko U.,Grdadolnik S.G.,Calhelha R.C.,Ferreira I.C.F.R.,Sankovic-Babic S.,Glamoclija J.,Fotopoulou T.,Koufaki M.,Zoumpoulakis P.,Sokovic M.
Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors
ChemMedChem, 13, 251-258, 2018

161
Rached W.,Zeghada F.Z.,Bennaceur M.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Carvalho A.M.,Marouf A.,Ferreira I.C.F.R.
Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves
Industrial Crops and Products, 112, 460-466, 2018

162
Rashed K.,Ćirič A.,Glamočlija J.,Calhelha R.,Ferreira I.,Soković M.
Identification of the bioactive constituents and the antibacterial, antifungal and cytotoxic activities of different fractions from Cestrum nocturnum L.
Jordan Journal of Biological Sciences, 11, 273-279, 2018

163
Lopes C.,Pereira E.,Soković M.,Carvalho A.,Barata A.,Lopes V.,Rocha F.,Calhelha R.,Barros L.,Ferreira I.
Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin
Molecules, 23, , 2018

164
Graça V.C.,Barros L.,Calhelha R.C.,Dias M.I.,Ferreira I.C.F.R.,Santos P.F.
Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity
Industrial Crops and Products, 108, 543-552, 2017

165
166
Oliveira F.S.,Ribeiro A.,Barros L.,Calhelha R.C.,Barreira J.C.M.,Junior B.D.,Abreu R.M.V.,Barreiro M.F.,Ferreira I.C.F.R.
Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)
Journal of Functional Foods, 38, 214-220, 2017

167
Jabeur I.,Pereira E.,Barros L.,Calhelha R.C.,Soković M.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents
Food Research International, 100, 717-723, 2017

168
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,González-Paramás A.M.,Barreiro M.F.,Ferreira I.C.F.R.
The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits
Food and Chemical Toxicology, 108, 139-147, 2017

169
Rached W.,Bennaceur M.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Carvalho A.M.,Marouf A.,Ferreira I.C.F.R.
Detailed phytochemical characterization and bioactive properties of: Myrtus nivelii Batt & Trab
Food and Function, 8, 3111-3119, 2017

170
Corrêa R.,Haminiuk C.,Barros L.,Dias M.,Calhelha R.,Kato C.,Correa V.,Peralta R.,Ferreira I.
Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
Journal of Functional Foods, 36, 410-417, 2017

171
Souilem F.,Fernandes Â.,Calhelha R.C.,Barreira J.C.M.,Barros L.,Skhiri F.,Martins A.,Ferreira I.C.F.R.
Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties
Food Chemistry, 230, 40-48, 2017

172
Chahdoura H.,Barreira J.C.M.,Adouni K.,Mhadhebi L.,Calhelha R.C.,Snoussi M.,Majdoub H.,Flamini G.,Ferreira I.C.F.R.,Achour L.
Bioactivity and chemical characterization of: Opuntia macrorhiza Engelm. seed oil: Potential food and pharmaceutical applications
Food and Function, 8, 2739-2747, 2017

173
Cardoso R.V.C.,Fernandes Â.,Oliveira M.B.P.P.,Calhelha R.C.,Barros L.,Martins A.,Ferreira I.C.F.R.
Development of nutraceutical formulations based on the mycelium of: Pleurotus ostreatus and Agaricus bisporus
Food and Function, 8, 2155-2164, 2017

174
Svobodova B.,Barros L.,Sopik T.,Calhelha R.C.,Heleno S.,Alves M.J.,Walcott S.,Kuban V.,Ferreira I.C.F.R.
Non-edible parts of Solanum stramoniifolium Jacq.-a new potent source of bioactive extracts rich in phenolic compounds for functional foods
Food and Function, 8, 2013-2021, 2017

175
Maisterra M.,Castro M.Á.,Muñoz-Centeno L.M.,Calhelha R.C.,Ferreira I.C.F.R.,García P.A.
Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E, and Revised Structure for Corticin A
Natural Product Communications, 12, 695-698, 2017

176
Jabeur I.,Martins N.,Barros L.,Calhelha R.C.,Vaz J.,Achour L.,Santos-Buelga C.,Ferreira I.C.F.R.
Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.
Food and Function, 8, 975-984, 2017

177
Pereira E.,Pimenta A.I.,Calhelha R.C.,Antonio A.L.,Barros L.,Santos-Buelga C.,Verde S.C.,Ferreira I.C.F.R.
Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
Industrial Crops and Products, 97, 582-590, 2017

178
Sobral F.,Calhelha R.,Barros L.,Dueñas M.,Tomás A.,Santos-Buelga C.,Vilas-Boas M.,Ferreira I.
Flavonoid composition and antitumor activity of bee bread collected in Northeast Portugal
Molecules, 22, , 2017

179
Magalhães F.,Graça V.C.,Calhelha R.C.,Ferreira I.C.F.R.,Santos P.F.
Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity
Bioorganic and Medicinal Chemistry Letters, 27, 4467-4470, 2017

180
Svobodova B.,Barros L.,Calhelha R.C.,Heleno S.,Alves M.J.,Walcott S.,Bittova M.,Kuban V.,Ferreira I.C.F.R.
Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago
Industrial Crops and Products, 95, 365-373, 2017

181
Rodrigues A.R.O.,Almeida B.G.,Rodrigues J.M.,Queiroz M.J.R.P.,Calhelha R.C.,Ferreira I.C.F.R.,Pires A.,Pereira A.M.,Araújo J.P.,Coutinho P.J.G.,Castanheira E.M.S.
Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
RSC Advances, 7, 15352-15361, 2017

182
Heleno S.A.,Rudke A.R.,Calhelha R.C.,Carocho M.,Barros L.,Gonçalves O.H.,Barreiro M.F.,Ferreira I.C.F.R.
Development of dairy beverages functionalized with pure ergosterol and mycosterol extracts: An alternative to phytosterol-based beverages
Food and Function, 8, 103-110, 2017

183
Jabeur I.,Tobaldini F.,Martins N.,Barros L.,Martins I.,Calhelha R.C.,Henriques M.,Silva S.,Achour L.,Santos-Buelga C.,Ferreira I.C.F.R.
Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile
Food Research International, 89, 422-431, 2016

184
Ferreira D.P.,Conceição D.S.,Calhelha R.C.,Sousa T.,Socoteanu R.,Ferreira I.C.F.R.,Vieira Ferreira L.F.
Porphyrin dye into biopolymeric chitosan films for localized photodynamic therapy of cancer
Carbohydrate Polymers, 151, 160-171, 2016

185
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,Barreiro M.F.,González-Paramás A.M.,Ferreira I.C.F.R.
Development of Mushroom-Based cosmeceutical formulations with Anti-Inflammatory, Anti-Tyrosinase, antioxidant, and antibacterial properties
Molecules, 21, , 2016

186
Ribeiro A.,Barros L.,Calhelha R.C.,Carocho M.,Ćirić A.,Sokovic M.,Dias M.M.,Santos-Buelga C.,Barreiro M.F.,Ferreira I.C.F.R.
Tarragon phenolic extract as a functional ingredient for pizza dough: Comparative performance with ascorbic acid (E300)
Journal of Functional Foods, 26, 268-278, 2016

187
Carocho M.,Barros L.,Barreira J.C.M.,Calhelha R.C.,Soković M.,Fernández-Ruiz V.,Buelga C.S.,Morales P.,Ferreira I.C.F.R.
Basil as functional and preserving ingredient in "serra da Estrela" cheese
Food Chemistry, 207, 51-59, 2016

188
Graça V.C.,Barros L.,Calhelha R.C.,Dias M.I.,Carvalho A.M.,Santos-Buelga C.,Santos P.F.,Ferreira I.C.F.R.
Chemical characterization and bioactive properties of aqueous and organic extracts of Geranium robertianum L.
Food and Function, 7, 3807-3814, 2016

189
Fotopoulou T.,Ćirić A.,Kritsi E.,Calhelha R.,Ferreira I.,Soković M.,Zoumpoulakis P.,Koufaki M.
Antimicrobial/Antibiofilm Activity and Cytotoxic Studies of β-Thujaplicin Derivatives
Archiv der Pharmazie, 698-709, 2016

190
Pereira E.,Pimenta A.I.,Calhelha R.C.,Antonio A.L.,Verde S.C.,Barros L.,Santos-Buelga C.,Ferreira I.C.F.R.
Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L.
LWT, 71, 370-377, 2016

191
Sobral F.,Sampaio A.,Falcão S.,Queiroz M.,Calhelha R.,Vilas-Boas M.,Ferreira I.
Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal
Food and Chemical Toxicology, 94, 172-177, 2016

192
Miguel M.,Barros L.,Pereira C.,Calhelha R.C.,Garcia P.A.,Castro M.Á.,Santos-Buelga C.,Ferreira I.C.F.R.
Chemical characterization and bioactive properties of two aromatic plants:: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)
Food and Function, 7, 2223-2232, 2016

193
Graça V.C.,Barros L.,Calhelha R.C.,Dias M.I.,Carvalho A.M.,Santos-Buelga C.,Ferreira I.C.F.R.,Santos P.F.
Chemical characterization and bioactive properties of: Geranium molle L.: From the plant to the most active extract and its phytochemicals
Food and Function, 7, 2204-2212, 2016

194
Chahdoura H.,Barreira J.C.M.,Fernández-Ruiz V.,Morales P.,Calhelha R.C.,Flamini G.,Soković M.,Ferreira I.C.F.R.,Achour L.
Bioactivity, proximate, mineral and volatile profiles along the flowering stages of Opuntia microdasys (Lehm.): Defining potential applications
Food and Function, 7, 1458-1467, 2016

195
Ferreira D.P.,Conceição D.S.,Fernandes F.,Sousa T.,Calhelha R.C.,Ferreira I.C.F.R.,Santos P.F.,Vieira Ferreira L.F.
Characterization of a Squaraine/Chitosan System for Photodynamic Therapy of Cancer
Journal of Physical Chemistry B, 120, 1212-1220, 2016

196
Liberal Â.,Calhelha R.C.,Pereira C.,Adega F.,Barros L.,Dueñas M.,Santos-Buelga C.,Abreu R.M.V.,Ferreira I.C.F.R.
A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: Red, white, and pink
Food and Function, 7, 679-688, 2016

197
Raposo C.D.,Petrova K.T.,Barros M.T.,Calhelha R.C.,Sokovi M.,Ferreira I.C.F.R.
Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate
Medicinal Chemistry, 12, 22-29, 2016

198
Valles E.,García P.A.,Miguel Del Corral J.M.,Pérez M.,Ferreira I.C.F.R.,Calhelha R.C.,San Feliciano A.,Castro M.Á.
Synthesis and cytotoxic evaluation of new terpenylpurines
RSC Advances, 6, 105412-105420, 2016

199
Rached W.,Calhelha R.C.,Fernandes Â.,Carvalho A.M.,Bennaceur M.,Marouf A.,Barros L.,Santos-Buelga C.,Ferreira I.C.F.R.
Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria
RSC Advances, 6, 72768-72776, 2016

200
Guimarães R.,Calhelha R.,Froufe H.,Abreu R.,Carvalho A.,Queiroz M.,Ferreira I.
Wild Roman chamomile extracts and phenolic compounds: Enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase
Food and Function, 7, 79-83, 2016

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