MOUNTAIN
RESEARCH
CENTER

Polytechnic Institute
of Bragança

image01

CIMO

CIMO - Mountain Research Center. See video HERE

FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.

Manuel Ricardo Calhelha

Group: Sustainable Processes and Products
Phone: 273330916
E-mail: calhelha@ipb.pt
ORCID: 0000-0002-6801-4578
Scopus Author ID: 6507978333

Career

  • Since 2019: Assistant at the Mountain Research Center of the Polytechnic Institute of Bragança (CIMO-IPB), Portugal
  • 2017 - 2019: Pos-Doc researcher in the project “Propriedades químicas e bioativas de produtos naturais obtidos a partir de matrizes vegetais e micológicas do Nordeste Transmontano” at Polytechnic Institute of Bragança (IPB), Portugal
  • 2011 - 2016: Pos-doc Researcher (SFRH/BPD/68344/2010)

Qualifications

  • 2010 - PhD. in Sciences, speciality in chemistry, University of Minho (UM), Portugal
  • 2003 - Graduation in Biotechnological engineering, Polytechnic Institute of Bragança (IPB), Portugal

Interests

  • Cytotoxicity activity using human tumor cell lines
  • Establishment of primary cell cultures from normal cells as toxicity models
  • Anti-inflammatory activity of using macrophages
  • Flow cytometry
  • Wound healing models

Projects:

TextBlueStyle - Obtenção de corantes azuis naturais e sustentáveis para aplicação têxtil
Funding body: Promove LA CAIXA
Reference:
Principal Investigator:Manuel Ricardo Costa Calhelha
Start: 2023-07-01
End: 2026-06-30
Mush4Chol - Development of an efficient hypocholesterolemic formulation from mushroom bioresidues through a sustainable integrated strategy
Funding body: FCT - PTDC - Projectos em todos os domínios científicos
Reference: 2022.08844.PTDC
Principal Investigator:Sandrina Alves Heleno
Start: 2023-03-01
End: 2026-02-28
WASTESILK - Silk Sericin as an industrial wastewater with valuable biomedical potential
Funding body: FCT - PTDC - Projectos em todos os domínios científicos
Reference: PTDC/BTA-BTA/0696/2020
Principal Investigator:Lillian Bouçada de Barros
Start: 2021-03-29
End: 2024-03-28
Bio4drinks - Obtenção de Ingredientes Naturais Multifuncionais para a Indústria de Bebidas
Funding body: NORTE 2020 - Programa Operacional Regional do Norte
Reference: NORTE-01-0247-FEDER-113508
Principal Investigator:Sandrina Alves Heleno
Start: 2021-09-01
End: 2023-06-30
PreVineGrape - Desenvolvimento de um biofungicida para combate a doenças da videira
Funding body: PORTUGAL 2020 - COMPETE 2020 - Programa Operacional Competitividade e Internacionalização
Reference: POCI-01-0247-FEDER-049695
Principal Investigator:Sandrina Alves Heleno
Start: 2021-01-01
End: 2023-06-29
MAGLIDUO - MAGnetoLIposomes for DUal cancer therapy
Funding body: PORTUGAL 2020 - COMPETE 2020 - Programa Operacional Competitividade e Internacionalização
Reference: POCI-01-0145-FEDER-028020
Principal Investigator:Lillian Bouçada de Barros
Start: 2018-07-01
End: 2021-12-31
IBERPHENOL - Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales
Funding body: POCTEP 2014-2020 - Programa de Cooperação Transfronteiriça Portugal – Espanha
Reference: 0377_IBERPHENOL_6_E
Principal Investigator:Lillian Bouçada de Barros
Start: 2015-10-01
End: 2020-12-31

Total results: 313
1
Lima L.,Pereira A.I.,Vaz C.B.,Ferreira O.,Dias M.I.,Heleno S.A.,Calhelha R.C.,Barros L.,Carocho M.
Optimization of heat and ultrasound-assisted extraction of Eucalyptus globulus leaves reveals strong antioxidant and antimicrobial properties
Food Chemistry, 479, , 2025

2
Añibarro-Ortega M.,Dias M.I.,Petrović J.,Núñez S.,Calhelha R.C.,Costa E.M.,Machado M.,Pintado M.,Soković M.,López V.,Barros L.,Pinela J.
Valorization of Solanum melongena L. crop by-products: Phenolic composition and in vitro antioxidant, antidiabetic, anti-inflammatory, cytotoxic, and antimicrobial properties
Process Biochemistry, 153, 315-324, 2025

3
Leichtweis M.G.,Molina A.K.,Dias M.I.,Calhelha R.C.,Pires T.C.S.P.,Pavli O.,Oliveira M.B.P.P.,Ferreira I.C.F.R.,Petropoulos S.A.,Barros L.,Pereira C.
Valorisation of pumpkin by-products: Chemical composition and bioactive properties of pumpkin seeds, peels, and fibrous strands from different local landraces of Greece
Food Chemistry, 475, , 2025

4
Fernandes F.A.,Roriz C.,Calhelha R.C.,Rodrigues P.,Pires T.C.S.P.,Prieto M.A.,Ferreira I.C.F.R.,Barros L.,Heleno S.A.
Valorization of natural resources - development of a functional plant-based beverage
Food Chemistry, 472, , 2025

5
Chelgham A.,Borges A.,Calhelha R.C.,Merouane A.,Noui A.,Saadi A.
Anti-Proliferative, Anti-Inflammatory, In Vitro Wound Healing Potentials and Phenolic Content of Phlomis Crinita Cav. Extracts
Tropical Journal of Natural Product Research, 9, 985-991, 2025

6
Barnabé M.L.d.F.,Vicente L.C.d.O.S.,Martins K.V.C.,Lacerda G.F.,Rodrigues E.,Oliveira L.A.,Dias K.A.,Pereira S.M.S.,José V.P.B.d.S.,Dias M.M.d.S.,Calhelha R.C.,Leite L.B.,Ribeiro L.,Carvalho I.M.M.d.,Silva B.P.d.,Martino H.S.D.,Gonçalves R.V.,Mattos Della Lucia C.
Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo
Nutrients, 17, , 2025

7
Plasencia P.,Finimundy T.C.,Carocho M.,Calhelha R.C.,Añibarro-Ortega M.,Pires T.C.S.P.,Barreiro F.,Garcia P.A.,Barros L.,Heleno S.A.
Extraction of Bioactive Compounds from Rubus Idaeus Bioresidues: A Full Screening on Phenolic Composition and Bioactive Potential
Waste and Biomass Valorization, 16, 737-747, 2025

8
Garcia-Perez P.,Garcia-Oliveira P.,Finimundy T.C.,Pinela J.,Calhelha R.C.,Nenadić M.,Soković M.,Simal-Gandara J.,Barros L.,Prieto M.A.
Authenticity and Bioactive Markers Search in the Phenolic-Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics
Food Science and Nutrition, 13, , 2025

9
Albuquerque B.R.,Pinela J.,Pereira C.,Calhelha R.C.,Oliveira I.,Heleno S.,Oliveira M.B.P.P.,Barros L.
Optimization and comparison of heat- and ultrasound-assisted extraction methods for anthocyanin recovery from Sicana odorifera fruit epicarp
Biomass Conversion and Biorefinery, 15, 1027-1040, 2025

10
Spréa R.M.,Finimundy T.C.,Calhelha R.C.,Pires T.C.S.P.,Prieto M.A.,Amaral J.S.,Barros L.
Comprehensive analysis of soybean (Glycine max L.) by-products: Nutritional value, phenolic composition, and bioactive properties
Food Bioscience, 62, , 2024

11
Radhouane M.F.,da Silveira T.F.F.,Ribeiro J.,Rodrigues P.,Guimarães R.,Calhelha R.,Mandim F.,Charfi I.,Ferreira I.C.F.R.,Alves M.J.,Barros L.,Heleno S.A.
Development, characterization and stability of a novel sport drink based on thermal water, apple juice and hibiscus
Food Chemistry Advances, 5, , 2024

12
Del Angelo G.L.,de Oliveira I.S.,de Albuquerque B.R.,Kagueyama S.S.,Vieira da Silva T.B.,dos Santos Filho J.R.,Dias M.I.,Pereira C.,Calhelha R.C.,Alves M.J.,Ferrari A.,Yamaguchi N.U.,Ferreira Zielinski A.A.,Bracht A.,Peralta R.M.,Corrêa R.C.G.
Jatoba (Hymenaea courbaril L.) Pod Residue: A Source of Phenolic Compounds as Valuable Biomolecules
Plants, 13, , 2024

13
Pires L.,Gonzalez-Paramás A.M.,Heleno S.A.,Calhelha R.C.
Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health
Applied Sciences (Switzerland), 14, , 2024

14
Casalvara R.F.A.,Santos E.d.S.,Mattos J.V.,Pimentel T.C.,Calhelha R.,Pires T.C.S.P.,Rodrigues D.B.,Pereira C.,Corrêa R.C.G.,Cardozo-Filho L.,Gonçalves J.E.
Chemical profile and bioactivities of industrial wastes from Chenopodium quinoa seed
European Journal of Lipid Science and Technology, 126, , 2024

15
de Oliveira I.,Chrysargyris A.,Finimundy T.C.,Carocho M.,Santos-Buelga C.,Calhelha R.C.,Tzortzakis N.,Barros L.,Heleno S.A.
The influence of magnesium and manganese cations on the chemical and bioactive properties of purple and green basil
Food and Function, 15, 10644-10662, 2024

16
Santos Filipe M.,Cardoso R.V.C.,Ayuso M.,Murta D.,Díaz-Lanza A.M.,Rosado C.,C.S.P Pires T.,Calhelha R.C.,Rijo P.
Exploring the potential of Hermetia illucens larvae extracts: A promising approach for dermocosmetic formulations
Heliyon, 10, , 2024

17
Polyzos N.,Fernandes Â.,Calhelha R.C.,Petrović J.,Soković M.,Ferreira I.C.F.R.,Barros L.,Petropoulos S.A.
Biochemical Composition of Pumpkin Seeds and Seed By-Products
Plants, 13, , 2024

18
19
Silva B.N.,Cadavez V.,Caleja C.,Pereira E.,Calhelha R.C.,Molina A.K.,Finimundy T.,Kostić M.,Soković M.,Teixeira J.A.,Barros L.,Gonzales-Barron U.
Chemical profiles and bioactivities of polyphenolic extracts of Lavandula stoechas L., Artemisia dracunculus L. and Ocimum basilicum L.
Food Chemistry, 451, , 2024

20
Pires L.,González-Paramás A.M.,Heleno S.A.,Calhelha R.C.
Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Antibiotics, 13, , 2024

21
Bouzaid H.,Espírito Santo L.,Ferreira D.M.,Machado S.,Costa A.S.G.,Dias M.I.,Calhelha R.C.,Barros L.,Chater O.,Rodi Y.K.,Errachidi F.,Chahdi F.O.,Oliveira M.B.P.P.,Alves R.C.
Detailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cumin
Molecules, 29, , 2024

22
Costa S.M.,Lourenço L.M.O.,Calhelha R.C.,Calejo I.,Barrias C.C.,Fangueiro R.,Ferreira D.P.
Localized cancer photodynamic therapy approach based on core-shell electrospun nanofibers
Materials Advances, 5, 6489-6500, 2024

23
Aragão M.Â.,Pires L.,Santos-Buelga C.,Barros L.,Calhelha R.C.
Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health
Foods, 13, , 2024

24
Spréa R.M.,Caleja C.,Finimundy T.C.,Calhelha R.C.,Pires T.C.S.P.,Amaral J.S.,Prieto M.A.,Ferreira I.C.F.R.,Pereira E.,Barros L.
Chemical and Bioactive Evaluation of Essential Oils from Edible and Aromatic Mediterranean Lamiaceae Plants
Molecules, 29, , 2024

25
Pires L.,González-Paramás A.M.,Heleno S.A.,Calhelha R.C.
The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases
Antibiotics, 13, , 2024

26
Polyzos N.,Paschoalinotto B.H.,Pires T.C.S.P.,Añibarro-Ortega M.,Calhelha R.,Ferreira I.C.F.R.,Dias M.I.,Barros L.,Petropoulos S.A.
The Impact of Deficit Irrigation on the Agronomic Performance and Chemical Composition of Scolymus hispanicus L.
Horticulturae, 10, , 2024

27
Baptista E.,Liberal Â.,Cardoso R.V.C.,Fernandes Â.,Dias M.I.,Pires T.C.S.P.,Calhelha R.C.,García P.A.,Ferreira I.C.F.R.,Barreira J.C.M.
Chemical and Bioactive Properties of Red Rice with Potential Pharmaceutical Use
Molecules, 29, , 2024

28
Pinto M.B.,Pires P.C.,Calhelha R.C.,Silva A.R.,Sousa M.J.,Vilas-Boas M.,Falcão S.I.,Veiga F.,Makvandi P.,Paiva-Santos A.C.
Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation
Pharmaceuticals, 17, , 2024

29
de Oliveira I.,Chrysargyris A.,Finimundy T.C.,Carocho M.,Santos-Buelga C.,Calhelha R.C.,Tzortzakis N.,Barros L.,Heleno S.A.
Magnesium and manganese induced changes on chemical, nutritional, antioxidant and antimicrobial properties of the pansy and Viola edible flowers
Food Chemistry, 438, , 2024

30
Albuquerque B.R.,Finimundy T.C.,Pinela J.,Pires T.C.S.P.,Calhelha R.C.,Vaz J.,Corrêa R.C.G.,Oliveira M.B.P.P.,Barros L.
Exploring the bioactive compounds from berry biowaste: Eugenia involucrata DC. as a study case
Food Bioscience, 58, , 2024

31
Mesias M.,Morales F.J.,Caleja C.,Pires T.C.S.P.,Calhelha R.C.,Barros L.,Pereira E.
Nutritional profiling, fiber content and in vitro bioactivities of wheat-based biscuits formulated with novel ingredients
Food and Function, 15, 4051-4064, 2024

32
Ames-Sibin A.P.,Chagas A.C.,Ferreira S.B.S.,Mandim F.,Finimundy T.C.,Calhelha R.C.,Peralta R.M.,Sá-Nakanishi A.B.,Bracht L.,Bruschi M.L.,Bracht A.,Barros L.,Comar J.F.
Characterization and bioactivity of copaiba essential oil carried in a self-nanoemulsifying drug delivery system
Journal of Drug Delivery Science and Technology, 91, , 2024

33
Pereira A.G.,Cassani L.,Oludemi T.,Chamorro F.,Calhelha R.C.,Prieto M.A.,Barros L.,Simal-Gandara J.,Lucini L.,Garcia-Perez P.
Untargeted metabolomics and in vitro functional analysis unravel the intraspecific bioactive potential of flowers from underexplored Camellia japonica cultivars facing their industrial application
Industrial Crops and Products, 204, , 2023

34
Leichtweis M.G.,Molina A.K.,Dias M.I.,Calhelha R.C.,Pires T.C.S.P.,Pavli O.,Oliveira M.B.P.P.,Petropoulos S.A.,Barros L.,Pereira C.
Variability in Chemical Profile and Bioactivities of the Flesh of Greek Pumpkin Landraces
Horticulturae, 9, , 2023

35
Larbi S.,Aylanc V.,Rodríguez-Flores M.S.,Calhelha R.C.,Barros L.,Rezouga F.,Seijo M.C.,Falcão S.I.,Vilas-Boas M.
Differentiating between Monofloral Portuguese Bee Pollens Using Phenolic and Volatile Profiles and Their Impact on Bioactive Properties
Molecules, 28, , 2023

36
Ueda J.M.,Griebler K.R.,Finimundy T.C.,Rodrigues D.B.,Veríssimo L.,Pires T.C.S.P.,Gonçalves J.,Fernandes I.P.,Pereira E.,Barros L.,Heleno S.A.,Calhelha R.C.
Polyphenol Composition by HPLC-DAD-(ESI-)MS/MS and Bioactivities of Extracts from Grape Agri-Food Wastes
Molecules, 28, , 2023

37
Santos de Carvalho A.,de Oliveira A.,Fernandes Moya Moreira T.,Gustavo Médice Arabel Costa L.,Donato Marcatto G.,da Silva Castilhos de Melo A.,Hess Gonçalves O.,Inês Dias M.,Calhelha R.C.,Barros L.,Valderrama P.,Cardozo Filho L.,Vitória Leimann F.
In situ extraction/encapsulation of olive leaves antioxidants in zein for improved oxidative stability of edible oils
Food Research International, 173, , 2023

38
Berretta A.A.,De Lima J.A.,Falcão S.I.,Calhelha R.,Amorim N.A.,Gonçalves I.S.,Zamarrenho L.G.,Barud H.d.S.,Bastos J.K.,De Jong D.,Vilas-Boas M.
Development and Characterization of High-Absorption Microencapsulated Organic Propolis EPP-AF® Extract (i-CAPs)
Molecules, 28, , 2023

39
Youssef S.,Custódio L.,Rodrigues M.J.,Pereira C.G.,Calhelha R.C.,Jekő J.,Cziáky Z.,Ben Hamed K.
Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile
Plants, 12, , 2023

40
Menezes B.,Caleja C.,Calhelha R.C.,Pinela J.,Dias M.I.,Stojković D.,Soković M.,Gonçalves O.H.,Leimann F.V.,Pereira E.,Barros L.
Use of Bio-Waste of Ilex paraguariensis A. St. Hil. (Yerba mate) to Obtain an Extract Rich in Phenolic Compounds with Preservative Potential
Foods, 12, , 2023

41
Plasencia P.,Heleno S.A.,Finimundy T.,Carocho M.,Calhelha R.C.,Añibarro-Ortega M.,Alves M.J.,Oludemi T.,Quidiongo N.,Barreiro F.,García P.A.,Ferreira I.C.F.R.,Barros L.
Recovery of High Valuable Bioactive Molecules from Vaccinium myrtillus L. Bioresidues
Waste and Biomass Valorization, 14, 2873-2884, 2023

42
Kessler J.C.,Vieira V.,Martins I.M.,Manrique Y.A.,Ferreira P.,Calhelha R.C.,Afonso A.,Barros L.,Rodrigues A.E.,Dias M.M.
The potential of almonds, hazelnuts, and walnuts SFE-CO2 extracts as sources of bread flavouring ingredients
Food Chemistry, 417, , 2023

43
de Oliveira I.,Chrysargyris A.,Heleno S.A.,Carocho M.,Calhelha R.C.,Dias M.I.,Petrović J.,Soković M.,Petropoulos S.A.,Santos-Buelga C.,Tzortzakis N.,Barros L.
Effects of the extraction techniques on the chemical composition and bioactive properties of lemon balm (Melissa officinalis L.) plants grown under different cropping and irrigation regimes
Food Research International, 170, , 2023

44
Rodrigues D.B.,Veríssimo L.,Finimundy T.,Rodrigues J.,Oliveira I.,Gonçalves J.,Fernandes I.P.,Barros L.,Heleno S.A.,Calhelha R.C.
Chemical and Bioactive Screening of Green Polyphenol-Rich Extracts from Chestnut By-Products: An Approach to Guide the Sustainable Production of High-Added Value Ingredients
Foods, 12, , 2023

45
Correia E.E.M.,Figueirinha A.,Rodrigues L.,Pinela J.,Calhelha R.C.,Barros L.,Fernandes C.,Salgueiro L.,Gonçalves T.
The Chemical Profile, and Antidermatophytic, Anti-Inflammatory, Antioxidant and Antitumor Activities of Withania chevalieri A.E. Gonç. Ethanolic Extract
Plants, 12, , 2023

46
Esteban L.S.,Mediavilla I.,Xavier V.,Amaral J.S.,Pires T.C.S.P.,Calhelha R.C.,López C.,Barros L.
Yield, Chemical Composition and Bioactivity of Essential Oils from Common Juniper (Juniperus communis L.) from Different Spanish Origins
Molecules, 28, , 2023

47
48
Inumaro R.S.,Casalvara R.F.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Calhelha R.M.,Heleno S.A.,Pimentel T.C.,Gonçalves J.E.,Cardozo-Filho L.
Supercritical fluid-assisted extraction of hop cone residue from craft breweries
Journal of CO2 Utilization, 72, , 2023

49
Mediavilla I.,Bados R.,Barros L.,Xavier V.,Finimundy T.C.,Pires T.C.S.P.,Heleno S.A.,Calhelha R.C.,Amaral J.S.,Rizzo A.M.,Casini D.,Lombardi G.,Chiaramonti D.,Cámara M.,Suárez A.,Ardid T.,Esteban L.S.
Assessment of the Use of Common Juniper (Juniperus communis L.) Foliage following the Cascade Principle
Molecules, 28, , 2023

50
Shiraishi C.S.H.,Zbiss Y.,Roriz C.L.,Dias M.I.,Prieto M.A.,Calhelha R.C.,Alves M.J.,Heleno S.A.,da Cunha Mendes V.,Carocho M.,Abreu R.M.V.,Barros L.
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes, 11, , 2023

51
Leichtweis M.G.,Molina A.K.,Petropoulos S.A.,Carocho M.,Pires T.C.S.P.,Dias M.I.,Calhelha R.,Oliveira M.B.P.P.,Pereira C.,Barros L.
Valorization of Pumpkin Peel as a Source of Bioactive Compounds: Optimization of Heat- and Ultrasound-Assisted Extraction
Molecules, 28, , 2023

52
Dridi A.,Reis F.S.,Pires T.C.S.P.,Calhelha R.C.,Pereira C.,Zaghdoudi K.,Ferreira I.C.F.R.,Barros L.,Barreira J.C.M.
Aesculus hippocastanum L.: A Simple Ornamental Plant or a Source of Compelling Molecules for Industry?
Separations, 10, , 2023

53
Silva B.N.,Cadavez V.,Caleja C.,Pereira E.,Calhelha R.C.,Añibarro-Ortega M.,Finimundy T.,Kostić M.,Soković M.,Teixeira J.A.,Barros L.,Gonzales-Barron U.
Phytochemical Composition and Bioactive Potential of Melissa officinalis L., Salvia officinalis L. and Mentha spicata L. Extracts
Foods, 12, , 2023

54
Albuquerque B.R.,Dias M.I.,Pinela J.,Calhelha R.C.,Pires T.C.S.P.,Alves M.J.,Corrêa R.C.G.,Ferreira I.C.F.R.,Oliveira M.B.P.P.,Barros L.
Insights into the Chemical Composition and In Vitro Bioactive Properties of Mangosteen (Garcinia mangostana L.) Pericarp
Foods, 12, , 2023

55
Albuquerque B.R.,Pinela J.,Dias M.I.,Pereira C.,Petrović J.,Soković M.,Calhelha R.C.,Oliveira M.B.P.P.,Ferreira I.C.F.R.,Barros L.
Valorization of rambutan (Nephelium lappaceum L.) peel: Chemical composition, biological activity, and optimized recovery of anthocyanins
Food Research International, 165, , 2023

56
Madureira J.,Albuquerque B.,Dias M.I.,Pinela J.,Calhelha R.C.,Santos-Buelga C.,Margaça F.M.A.,Ferreira I.C.F.R.,Cabo Verde S.,Barros L.
Ultrasound-assisted extraction of hydroxytyrosol and tyrosol from olive pomace treated by gamma radiation: process optimization and bioactivity assessment
Food and Function, 14, 3038-3050, 2023

57
Calhelha R.C.,Shiraishi C.S.H.,Ribeiro L.,Carocho M.,Abreu R.,Coutinho P.,Barros L.,Vaz J.,Ferreira I.C.F.R.
New trends from fungi secondary metabolism in the pharmaceutical industry
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 823-850, 2023

58
Calhelha R.C.,Haddad H.,Ribeiro L.,Heleno S.A.,Carocho M.,Barros L.
Inflammation: What’s There and What’s New?
Applied Sciences (Switzerland), 13, , 2023

59
Calheiros D.,Dias M.I.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.,Fernandes C.,Gonçalves T.
Antifungal Activity of Spent Coffee Ground Extracts
Microorganisms, 11, , 2023

60
Ueda J.M.,Milho C.,Heleno S.A.,Soria-Lopez A.,Carpena M.,Alves M.J.,Pires T.,Prieto M.A.,Simal-Gandara J.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.
Emerging Strategies to Combat Methicillin-resistant Staphylococcus aureus (MRSA): Natural Agents with High Potential
Current Pharmaceutical Design, 29, 837-851, 2023

61
Kostić M.,Ivanov M.,Fernandes Â.,Calhelha R.C.,Glamočlija J.,Barros L.,Soković M.,Ćirić A.
A Comparative Study of Lactarius Mushrooms: Chemical Characterization, Antibacterial, Antibiofilm, Antioxidant and Cytotoxic Activity
Journal of Fungi, 9, , 2023

62
Aylanc V.,Larbi S.,Calhelha R.,Barros L.,Rezouga F.,Rodríguez-Flores M.S.,Seijo M.C.,El Ghouizi A.,Lyoussi B.,Falcão S.I.,Vilas-Boas M.
Evaluation of Antioxidant and Anticancer Activity of Mono- and Polyfloral Moroccan Bee Pollen by Characterizing Phenolic and Volatile Compounds
Molecules, 28, , 2023

63
Fischer T.E.,Marcondes A.,Zardo D.M.,Nogueira A.,Calhelha R.C.,Vaz J.A.,Barros L.,Zielinski A.A.F.,Alberti A.
Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia
Antioxidants, 11, , 2022

64
Leichtweis M.G.,Molina A.K.,Pires T.C.S.,Dias M.I.,Calhelha R.,Bachari K.,Ziani B.E.C.,Oliveira M.B.P.P.,Pereira C.,Barros L.
Biological Activity of Pumpkin Byproducts: Antimicrobial and Antioxidant Properties
Molecules, 27, , 2022

65
Zaier M.M.,Heleno S.A.,Mandim F.,Calhelha R.C.,Ferreira I.C.F.R.,Achour L.,Kacem A.,Dias M.I.,Barros L.
Effects of the seasonal variation in the phytochemical composition and bioactivities of the wild halophyte Suaeda fruticosa
Food Bioscience, 50, , 2022

66
67
Youssef S.,Custódio L.,Rodrigues M.J.,Pereira C.G.,Calhelha R.C.,Pinela J.,Barros L.,Jekő J.,Cziáky Z.,Ben Hamed K.
Nutritional anti-nutritional chemical composition and antioxidant activities of the leaves of the sea cliff dwelling species Limonium spathulatum (Desf.) Kuntze
Frontiers in Plant Science, 13, , 2022

68
Silva A.S.,Costa E.C.,Reis S.,Spencer C.,Calhelha R.C.,Miguel S.P.,Ribeiro M.P.,Barros L.,Vaz J.A.,Coutinho P.
Silk Sericin: A Promising Sustainable Biomaterial for Biomedical and Pharmaceutical Applications
Polymers, 14, , 2022

69
de la Fuente B.,Pinela J.,Calhelha R.C.,Heleno S.A.,Ferreira I.C.F.R.,Barba F.J.,Berrada H.,Caleja C.,Barros L.
Sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) head oils recovered by microwave-assisted extraction: Nutritional quality and biological properties
Food and Bioproducts Processing, 136, 97-105, 2022

70
Mascoloti Spréa R.,Caleja C.,Pinela J.,Finimundy T.C.,Calhelha R.C.,Kostić M.,Sokovic M.,Prieto M.A.,Pereira E.,Amaral J.S.,Barros L.
Comparative study on the phenolic composition and in vitro bioactivity of medicinal and aromatic plants from the Lamiaceae family
Food Research International, 161, , 2022

71
Garcia-Manieri J.A.A.,Correa V.G.,Corrêa R.C.G.,Dias M.I.,Calhelha R.C.,Ivanov M.,Soković M.,Barros L.,Ferreira I.C.F.R.,Bracht A.,Peralta R.M.
Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems
Biocatalysis and Agricultural Biotechnology, 45, , 2022

72
Polyzos N.,Paschoalinotto B.H.,Compocholi M.,Pinela J.,Heleno S.A.,Calhelha R.C.,Dias M.I.,Barros L.,Petropoulos S.A.
Fertilization of Pot-Grown Cichorium spinosum L.: How It Can Affect Plant Growth, Chemical Profile, and Bioactivities of Edible Parts?
Horticulturae, 8, , 2022

73
Garcia-Oliveira P.,Carreira-Casais A.,Pereira E.,Dias M.I.,Pereira C.,Calhelha R.C.,Stojković D.,Sokovic M.,Simal-Gandara J.,Prieto M.A.,Caleja C.,Barros L.
From Tradition to Health: Chemical and Bioactive Characterization of Five Traditional Plants
Molecules, 27, , 2022

74
da Silva Santos É.,Savam A.,Cabral M.R.P.,Castro J.C.,de Oliveira Collet S.A.,Mandim F.,Calhelha R.C.,Barros L.,da Silva Machado M.d.F.P.,de Oliveira A.J.B.,Gonçalves R.A.C.
Low-cost alternative for the bioproduction of bioactive phenolic compounds of callus cultures from Cereus hildmannianus (K.) Schum
Journal of Biotechnology, 356, 8-18, 2022

75
Moreira B.,Pereira E.,Finimundy T.C.,Pinela J.,Calhelha R.C.,Carocho M.,Stojković D.,Sokovic M.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Pineapple by-products as a source of bioactive compounds with potential for industrial food application
Food and Function, 13, 9959-9972, 2022

76
Vieira D.M.,Pereira C.,Calhelha R.C.,Barros L.,Petrovic J.,Sokovic M.,Barreiro M.F.,Ferreira I.C.F.R.,Castro M.C.R.,Rodrigues P.V.,Machado A.V.
Evaluation of plant extracts as an efficient source of additives for active food packaging
Food Frontiers, 3, 480-488, 2022

77
Nicolescu A.,Babotă M.,Ilea M.,Dias M.I.,Calhelha R.C.,Gavrilaș L.,Rocchetti G.,Crișan G.,Mocan A.,Barros L.,Pârvu A.E.
Potential therapeutic applications of infusions and hydroalcoholic extracts of Romanian glutinous sage (Salvia glutinosa L.)
Frontiers in Pharmacology, 13, , 2022

78
Kessler J.C.,Vieira V.,Martins I.M.,Manrique Y.A.,Ferreira P.,Calhelha R.C.,Afonso A.,Barros L.,Rodrigues A.E.,Dias M.M.
Chemical and organoleptic properties of bread enriched with Rosmarinus officinalis L.: The potential of natural extracts obtained through green extraction methodologies as food ingredients
Food Chemistry, 384, , 2022

79
Mocan A.,Fernandes Â.,Calhelha R.C.,Gavrilaş L.,Ferreira I.C.F.R.,Ivanov M.,Sokovic M.,Barros L.,Babotă M.
Bioactive Compounds and Functional Properties of Herbal Preparations of Cystus creticus L. Collected From Rhodes Island
Frontiers in Nutrition, 9, , 2022

80
Alonso-Esteban J.I.,Pinela J.,Ćirić A.,Calhelha R.C.,Soković M.,Ferreira I.C.F.R.,Barros L.,Torija-Isasa E.,Sánchez-Mata M.d.C.
Chemical composition and biological activities of whole and dehulled hemp (Cannabis sativa L.) seeds
Food Chemistry, 374, , 2022

81
Derbassi N.,C. Pedrosa M.,Heleno S.,Fernandes F.,Dias M.I.,Calhelha R.C.,Rodrigues P.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Arbutus unedo leaf extracts as potential dairy preservatives: case study on quark cheese
Food and Function, 13, 5442-5454, 2022

82
Roriz C.L.,Heleno S.A.,Alves M.J.,Oliveira M.B.P.P.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Red pitaya (Hylocereus costaricensis) peel as a source of valuable molecules: Extraction optimization to recover natural colouring agents
Food Chemistry, 372, , 2022

83
Silva A.R.,Ayuso M.,Pereira C.,Dias M.I.,Kostić M.,Calhelha R.C.,Soković M.,García P.A.,Ferreira I.C.F.R.,Barros L.
Evaluation of parasite and host phenolic composition and bioactivities − The Practical Case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter
Industrial Crops and Products, 176, , 2022

84
Kostić M.,Ivanov M.,Markovic T.,Sanković Babić S.,Barros L.,Calhelha R.,Sokovic M.,Ciric A.
An in vitro study of the origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: antibacterial, antibiofilm, antioxidant, and cytotoxic activities
Journal of Essential Oil Research, 34, 533-543, 2022

85
Bortolucci W.d.C.,Raimundo K.F.,Fernandez C.M.M.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.,Gonçalves J.E.,Linde G.A.,Colauto N.B.,Gazim Z.C.
Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil
Natural Product Research, 36, 2878-2883, 2022

86
Nikolić M.,Marković T.,Marković D.,Calhelha R.C.,Fernandes Â.,Ferreira I.C.F.R.,Stojković D.,Ćirić A.,Glamočlija J.,Soković M.
Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute
Journal of the Serbian Chemical Society, 86, 1291-1303, 2021

87
Tedjini R.,Ziani B.E.C.,Casimiro T.,Viveiros R.,Calhelha R.C.,Barros L.,Boukenna L.,Hamdi A.,Chebout R.,Bachari K.,Talhi O.,Silva A.M.S.
Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)
Journal of Molecular Structure, 1246, , 2021

88
Mehdi I.E.,Falcão S.I.,Harandou M.,Boujraf S.,Calhelha R.C.,Ferreira I.C.F.R.,Anjos O.,Campos M.G.,Vilas-Boas M.
Chemical, cytotoxic, and anti-inflammatory assessment of honey bee venom from apis mellifera intermissa
Antibiotics, 10, , 2021

89
Xavier V.,Finimundy T.C.,Heleno S.A.,Amaral J.S.,Calhelha R.C.,Vaz J.,Pires T.C.S.P.,Mediavilla I.,Esteban L.S.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive characterization of the essential oils obtained from three mediterranean plants
Molecules, 26, , 2021

90
Sampaio S.L.,Petropoulos S.A.,Dias M.I.,Pereira C.,Calhelha R.C.,Fernandes Â.,Leme C.M.M.,Alexopoulos A.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.
Phenolic composition and cell-based biological activities of ten coloured potato peels (Solanum tuberosum L.)
Food Chemistry, 363, , 2021

91
Rio I.S.R.,Rodrigues A.R.O.,Rodrigues J.M.,Queiroz M.J.R.P.,Calhelha R.C.,Ferreira I.C.F.R.,Almeida B.G.,Pires A.,Pereira A.M.,Araújo J.P.,Castanheira E.M.S.,Coutinho P.J.G.
Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapy
Pharmaceutics, 13, , 2021

92
Añibarro-Ortega M.,Pinela J.,Ćirić A.,Lopes E.,Molina A.K.,Calhelha R.C.,Soković M.,Ferreira O.,Ferreira I.C.F.R.,Barros L.
Extraction of aloesin from aloe vera rind using alternative green solvents: Process optimization and biological activity assessment
Biology, 10, , 2021

93
Pires E.d.O.,Pereira E.,Carocho M.,Pereira C.,Dias M.I.,Calhelha R.C.,Ćirić A.,Soković M.,Garcia C.C.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Study on the potential application of impatiens balsamina l. Flowers extract as a natural colouring ingredient in a pastry product
International Journal of Environmental Research and Public Health, 18, , 2021

94
95
Giordano M.,Pinela J.,Dias M.I.,Calhelha R.C.,Stojković D.,Soković M.,Tavares D.,Cánepa A.L.,Ferreira I.C.F.R.,Caleja C.,Barros L.
Ultrasound-assisted extraction of flavonoids from kiwi peel: Process optimization and bioactivity assessment
Applied Sciences (Switzerland), 11, , 2021

96
Petropoulos S.A.,Fernandes Â.,Calhelha R.C.,Rouphael Y.,Petrović J.,Soković M.,Ferreira I.C.F.R.,Barros L.
Antimicrobial properties, cytotoxic effects, and fatty acids composition of vegetable oils from purslane, linseed, luffa, and pumpkin seeds
Applied Sciences (Switzerland), 11, , 2021

97
Alaya I.B.,Pereira E.,Dias M.I.,Pinela J.,Calhelha R.C.,Soković M.,Kostić M.,Prieto M.A.,Essid F.,Caleja C.,Ferreira I.C.F.R.,Barros L.
Development of a natural preservative from chestnut flowers: Ultrasound-assisted extraction optimization and functionality assessment
Chemosensors, 9, , 2021

98
Ceccanti C.,Finimundy T.C.,Heleno S.A.,Pires T.C.S.P.,Calhelha R.C.,Guidi L.,Ferreira I.C.F.R.,Barros L.
Differences in the phenolic composition and nutraceutical properties of freeze dried and oven-dried wild and domesticated samples of Sanguisorba minor Scop
LWT, 145, , 2021

99
Roriz C.L.,Xavier V.,Heleno S.A.,Pinela J.,Dias M.I.,Calhelha R.C.,Morales P.,Ferreira I.C.F.R.,Barros L.
Chemical and bioactive features of amaranthus caudatus l. Flowers and optimized ultrasound-assisted extraction of betalains
Foods, 10, , 2021

100
Rodrigues J.P.B.,Fernandes Â.,Dias M.I.,Pereira C.,Pires T.C.S.P.,Calhelha R.C.,Carvalho A.M.,Ferreira I.C.F.R.,Barros L.
Phenolic compounds and bioactive properties of Ruscus aculeatus L. (asparagaceae): The pharmacological potential of an underexploited subshrub
Molecules, 26, , 2021

101
Albuquerque B.R.,Dias M.I.,Pereira C.,Petrović J.,Soković M.,Calhelha R.C.,Oliveira M.B.P.P.,Ferreira I.C.F.R.,Barros L.
Valorization of sicana odorifera (Vell.) naudin epicarp as a source of bioactive compounds: Chemical characterization and evaluation of its bioactive properties
Foods, 10, , 2021

102
García-Pérez P.,Ayuso M.,Lozano-Milo E.,Pereira C.,Dias M.I.,Ivanov M.,Calhelha R.C.,Soković M.,Ferreira I.C.F.R.,Barros L.,Gallego P.P.
Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants
Industrial Crops and Products, 162, , 2021

103
Fernandes Â.,Bancessi A.,Pinela J.,Dias M.I.,Liberal Â.,Calhelha R.C.,Ćirić A.,Soković M.,Catarino L.,Ferreira I.C.F.R.,Barros L.
Nutritional and phytochemical profiles and biological activities of Moringa oleifera Lam. edible parts from Guinea-Bissau (West Africa)
Food Chemistry, 341, , 2021

104
Novais C.,Pereira C.,Molina A.K.,Liberal Â.,Dias M.I.,Añibarro-Ortega M.,Alves M.J.,Calhelha R.C.,Ferreira I.C.F.R.,Barros L.
Bioactive and nutritional potential of medicinal and aromatic plant (Map) seasoning mixtures
Molecules, 26, , 2021

105
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.C.,Ivanov M.,Sokovic M.D.,Ferreira I.C.F.R.,Barros L.
Effects of growing substrate and nitrogen fertilization on the chemical composition and bioactive properties of centaurea raphanina Ssp. Mixta (dc.) Runemark
Agronomy, 11, , 2021

106
Ueda J.M.,Pedrosa M.C.,Fernandes F.A.,Rodrigues P.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.A.,Carocho M.,Ineu R.P.,Ferreira I.C.F.R.,Barros L.
Promising preserving agents from sage and basil: A case study with yogurts
Foods, 10, , 2021

107
Paschoalinotto B.H.,Dias M.I.,Pinela J.,Pires T.C.S.P.,Alves M.J.,Mocan A.,Calhelha R.C.,Barros L.,Ineu R.P.,Ferreira I.C.F.R.
Phytochemical characterization and evaluation of bioactive properties of tisanes prepared from promising medicinal and aromatic plants
Foods, 10, 1-26, 2021

108
Tejedor-Calvo E.,Amara K.,Reis F.S.,Barros L.,Martins A.,Calhelha R.C.,Venturini M.E.,Blanco D.,Redondo D.,Marco P.,Ferreira I.C.F.R.
Chemical composition and evaluation of antioxidant, antimicrobial and antiproliferative activities of Tuber and Terfezia truffles
Food Research International, 140, , 2021

109
Ribeiro A.S.,Costa S.M.,Ferreira D.P.,Calhelha R.C.,Barros L.,Stojković D.,Soković M.,Ferreira I.C.F.R.,Fangueiro R.
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
Reactive and Functional Polymers, 159, , 2021

110
Gómez-Mejía E.,Roriz C.L.,Heleno S.A.,Calhelha R.,Dias M.I.,Pinela J.,Rosales-Conrado N.,León-González M.E.,Ferreira I.C.F.R.,Barros L.
Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential
Food Chemistry, 337, , 2021

111
Ivanov M.,Kannan A.,Stojković D.S.,Glamočlija J.,Calhelha R.C.,Ferreira I.C.F.R.,Sanglard D.,Soković M.
Camphor and eucalyptol—anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity
International Journal of Molecular Sciences, 22, 1-14, 2021

112
Pires E.d.O.,Pereira E.,Pereira C.,Dias M.I.,Calhelha R.C.,Ćirić A.,Soković M.,Hassemer G.,Garcia C.C.,Caleja C.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive characterisation of Impatiens walleriana
Molecules, 26, , 2021

113
Pedrosa M.C.,Ueda J.M.,Melgar B.,Dias M.I.,Pinela J.,Calhelha R.C.,Ivanov M.,Soković M.,Heleno S.,da Silva A.B.,Carocho M.,Ferreira I.C.F.R.,Barros L.
Preservation of chocolate muffins with Lemon Balm, Oregano, and Rosemary extracts
Foods, 10, , 2021

114
Ivanov M.,Kannan A.,Stojković D.S.,Glamočlija J.,Calhelha R.C.,Ferreira I.C.F.R.,Sanglard D.,Soković M.
Flavones, flavonols, and glycosylated derivatives—impact on candida albicans growth and virulence, expression of cdr1 and erg11, cytotoxicity
Pharmaceuticals, 14, 1-12, 2021

115
Pantuzza Silva G.F.,Pereira E.,Melgar B.,Stojković D.,Sokovic M.,Calhelha R.C.,Pereira C.,Abreu R.M.V.,Ferreira I.C.F.R.,Barros L.
Eggplant fruit (Solanum melongena l.) and bio‐residues as a source of nutrients, bioactive compounds, and food colorants, using innovative food technologies
Applied Sciences (Switzerland), 11, 1-24, 2021

116
Pires T.C.S.P.,Inês Dias M.,Calhelha R.C.,José Alves M.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.
Development of new bilberry (Vaccinium myrtillus L.) based snacks: Nutritional, chemical and bioactive features
Food Chemistry, 334, , 2021

117
Pereira E.,Cadavez V.,Barros L.,Encina-Zelada C.,Stojković D.,Sokovic M.,Calhelha R.C.,Gonzales-Barron U.,Ferreira I.C.F.R.
Chenopodium quinoa Willd. (quinoa) grains: A good source of phenolic compounds
Food Research International, 137, , 2020

118
Finimundy T.C.,Karkanis A.,Fernandes Â.,Petropoulos S.A.,Calhelha R.,Petrović J.,Soković M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes
Food Chemistry, 327, , 2020

119
Petropoulos S.A.,Fernandes Â.,Plexida S.,Pereira C.,Dias M.I.,Calhelha R.,Chrysargyris A.,Tzortzakis N.,Petrović J.,Soković M.D.,Ferreira I.C.F.R.,Barros L.
The sustainable use of cotton, hazelnut and ground peanut waste in vegetable crop production
Sustainability (Switzerland), 12, 1-17, 2020

120
Kostić M.,Ivanov M.,Fernandes Â.,Pinela J.,Calhelha R.C.,Glamočlija J.,Barros L.,Ferreira I.C.F.R.,Soković M.,Ćirić A.
Antioxidant extracts of three russula genus species express diverse biological activity
Molecules, 25, , 2020

121
Ziani B.E.C.,Carocho M.,Abreu R.M.V.,Bachari K.,Alves M.J.,Calhelha R.C.,Talhi O.,Barros L.,Ferreira I.C.F.R.
Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts
Food Bioscience, 36, , 2020

122
Madureira J.,Dias M.I.,Pinela J.,Calhelha R.C.,Barros L.,Santos-Buelga C.,Margaça F.M.A.,Ferreira I.C.F.R.,Cabo Verde S.
The use of gamma radiation for extractability improvement of bioactive compounds in olive oil wastes
Science of the Total Environment, 727, , 2020

123
Spréa R.M.,Fernandes Â.,Finimundy T.C.,Pereira C.,Alves M.J.,Calhelha R.C.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Lovage (Levisticum officinale W.D.J. Koch) roots: A source of bioactive compounds towards a circular economy
Resources, 9, , 2020

124
Ghada B.,Pereira E.,Pinela J.,Prieto M.A.,Pereira C.,Calhelha R.C.,Stojkovic D.,Sokóvic M.,Zaghdoudi K.,Barros L.,Ferreira I.C.F.R.
Recovery of anthocyanins from passion fruit epicarp for food colorants: Extraction process optimization and evaluation of bioactive properties
Molecules, 25, , 2020

125
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelh R.C.,Ivanov M.,Sokovi M.D.,Ferreira I.C.F.R.,Barros L.
The effect of nitrogen fertigation and harvesting time on plant growth and chemical composition of centaurea raphanina subsp. mixta (DC.) Runemark
Molecules, 25, , 2020

126
Coelho J.,Barros L.,Dias M.I.,Finimundy T.C.,Amaral J.S.,Alves M.J.,Calhelha R.C.,Santos P.F.,Ferreira I.C.F.R.
Echinacea purpurea (L.) moench: Chemical characterization and bioactivity of its extracts and fractions
Pharmaceuticals, 13, 1-16, 2020

127
Vieira V.,Calhelha R.C.,Barros L.,Coutinho J.A.P.,Ferreira I.C.F.R.,Ferreira O.
Insights on the extraction performance of alkanediols and glycerol: Using Juglans regia L. Leaves as a source of bioactive compounds
Molecules, 25, , 2020

128
Ayuso M.,Pinela J.,Dias M.I.,Barros L.,Ivanov M.,Calhelha R.C.,Soković M.,Ramil-Rego P.,Barreal M.E.,Gallego P.P.,Ferreira I.C.F.R.
Phenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gay
Industrial Crops and Products, 148, , 2020

129
Pinela J.,Omarini A.B.,Stojković D.,Barros L.,Postemsky P.D.,Calhelha R.C.,Breccia J.,Fernández-Lahore M.,Soković M.,Ferreira I.C.F.R.
Biotransformation of rice and sunflower side-streams by dikaryotic and monokaryotic strains of Pleurotus sapidus: Impact on phenolic profiles and bioactive properties
Food Research International, 132, , 2020

130
131
Gonzales-Barron U.,Dijkshoorn R.,Maloncy M.,Finimundy T.,Calhelha R.C.,Pereira C.,Stojković D.,Soković M.,Ferreira I.C.F.R.,Barros L.,Cadavez V.
Nutritive and bioactive properties of mesquite (prosopis pallida) flour and its technological performance in breadmaking
Foods, 9, , 2020

132
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.C.,Chrysargyris A.,Tzortzakis N.,Ivanov M.,Sokovic M.D.,Barros L.,Ferreira I.C.F.R.
Chemical composition and plant growth of Centaurea raphanina subsp. mixta plants cultivated under saline conditions
Molecules, 25, , 2020

133
Finimundy T.C.,Pereira C.,Dias M.I.,Caleja C.,Calhelha R.C.,Sokovic M.,Stojković D.,Carvalho A.M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Infusions of herbal blends as promising sources of phenolic compounds and bioactive properties
Molecules, 25, , 2020

134
Majdi C.,Pereira C.,Dias M.I.,Calhelha R.C.,Alves M.J.,Frih B.,Charrouf Z.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Phytochemical characterization and bioactive properties of cinnamon basil (Ocimum basilicum cv. ‘cinnamon’) and lemon basil (ocimum x citriodorum)
Antioxidants, 9, , 2020

135
Sampaio S.L.,Fernandes Â.,Pereira C.,Calhelha R.C.,Sokovic M.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
Nutritional value, physicochemical characterization and bioactive properties of the Brazilian quinoa: BRS Piabiru
Food and Function, 11, 2969-2977, 2020

136
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.,Di Gioia F.,Tzortzakis N.,Ivanov M.,Sokovic M.,Barros L.,Ferreira I.C.F.R.
Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds
Antioxidants, 9, , 2020

137
Albuquerque B.R.,Pereira C.,Calhelha R.C.,José Alves M.,Abreu R.M.V.,Barros L.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties
Food Chemistry, 309, , 2020

138
Caleja C.,Barros L.,Barreira J.C.M.,Soković M.,Calhelha R.C.,Bento A.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Castanea sativa male flower extracts as an alternative additive in the Portuguese pastry delicacy "pastel de nata"
Food and Function, 11, 2208-2217, 2020

139
Vieira V.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Coutinho J.A.P.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals
Food and Chemical Toxicology, 137, , 2020

140
Spréa R.M.,Fernandes Â.,Calhelha R.C.,Pereira C.,Pires T.C.S.P.,Alves M.J.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Chemical and bioactive characterization of the aromatic plant: Levisticum officinale W.D.J. Koch: a comprehensive study
Food and Function, 11, 1292-1303, 2020

141
Silva A.R.,Pinela J.,Dias M.I.,Calhelha R.C.,Alves M.J.,Mocan A.,García P.A.,Barros L.,Ferreira I.C.F.R.
Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties
Food and Chemical Toxicology, 136, , 2020

142
Lageiro M.M.,Castanho A.,Pereira C.,Calhelha R.C.,Ferreira I.C.F.R.,Brites C.
Assessment of gamma oryzanol variability, an attractive rice bran bioactive compound
Emirates Journal of Food and Agriculture, 32, 38-46, 2020

143
da Silva Veloso F.,Caleja C.,Calhelha R.C.,Pires T.C.S.,Alves M.J.,Barros L.,Genena A.K.,Barreira J.C.M.,Ferreira I.C.F.R.
Characterization and application of pomegranate epicarp extracts as functional ingredients in a typical Brazilian pastry product
Molecules, 25, , 2020

144
Conceição N.,Albuquerque B.R.,Pereira C.,Corrêa R.C.G.,Lopes C.B.,Calhelha R.C.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
By-products of camu-camu [Myrciaria dubia (Kunth) McVaugh] as promising sources of bioactive high added-value food ingredients: Functionalization of yogurts
Molecules, 25, , 2020

145
Dias M.,Caleja C.,Pereira C.,Calhelha R.C.,Kostic M.,Sokovic M.,Tavares D.,Baraldi I.J.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive properties of byproducts from two different kiwi varieties
Food Research International, 127, , 2020

146
Ferreira L.F.V.,Machado I.F.,Gama A.,Socoteanu R.P.,Boscencu R.,Manda G.,Calhelha R.C.,Ferreira I.C.F.R.
Photochemical /photocytotoxicity studies of new tetrapyrrolic structures as potential candidates for cancer theranostics
Current Drug Discovery Technologies, 17, 661-669, 2020

147
Graça V.C.,Calhelha R.C.,Nunes F.M.,Berthet J.,Ferreira I.C.F.R.,Santos P.F.
Isolation of secondary metabolites from Geranium molle L. with anticancer potential
Industrial Crops and Products, 142, , 2019

148
Pereira C.,Dias M.I.,Petropoulos S.A.,Plexida S.,Chrysargyris A.,Tzortzakis N.,Calhelha R.C.,Ivanov M.,Stojković D.,Soković M.,Barros L.,Ferreira I.C.F.R.
The effects of biostimulants, biofertilizers and water-stress on nutritional value and chemical composition of two spinach genotypes (Spinacia oleracea L.)
Molecules, 24, , 2019

149
Ćirić A.,Kruljević I.,Stojković D.,Fernandes Â.,Barros L.,Calhelha R.C.,Ferreira I.C.F.R.,Soković M.,Glamočlija J.
Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: Functional foods with diverse biological activities
Food and Function, 10, 7678-7686, 2019

150
Chihoub W.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Valorisation of the green waste parts from turnip, radish and wild cardoon: Nutritional value, phenolic profile and bioactivity evaluation
Food Research International, 126, , 2019

151
Petropoulos S.A.,Fernandes Â.,Calhelha R.C.,Di Gioia F.,Kolovou P.,Barros L.,Ferreira I.C.F.R.
Chemical composition and bioactive properties of Cichorium spinosum L. in relation to nitrate/ammonium nitrogen ratio
Journal of the Science of Food and Agriculture, 99, 6741-6750, 2019

152
Afonso A.F.,Pereira O.R.,Fernandes Â.,Calhelha R.C.,Silva A.M.S.,Ferreira R.C.F.,Cardoso S.M.
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts
Molecules, 24, , 2019

153
Campestrini L.H.,Melo P.S.,Peres L.E.P.,Calhelha R.C.,Ferreira I.C.F.R.,Alencar S.M.
A new variety of purple tomato as a rich source of bioactive carotenoids and its potential health benefits
Heliyon, 5, , 2019

154
Harumi Iyda J.,Fernandes Â.,Calhelha R.C.,Alves M.J.,Ferreira F.D.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Nutritional composition and bioactivity of Umbilicus rupestris (Salisb.)Dandy: An underexploited edible wild plant
Food Chemistry, 295, 341-349, 2019

155
Añibarro-Ortega M.,Pinela J.,Barros L.,Ćirić A.,Silva S.P.,Coelho E.,Mocan A.,Calhelha R.C.,Soković M.,Coimbra M.A.,Ferreira I.C.F.R.
Compositional features and bioactive properties of aloe vera leaf (Fillet, mucilage, and rind) and flower
Antioxidants, 8, , 2019

156
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest
Food Chemistry, 294, 302-308, 2019

157
Arribas C.,Pereira E.,Barros L.,Alves M.J.,Calhelha R.C.,Guillamón E.,Pedrosa M.M.,Ferreira I.C.F.R.
Healthy novel gluten-free formulations based on beans, carob fruit and rice: Extrusion effect on organic acids, tocopherols, phenolic compounds and bioactivity
Food Chemistry, 292, 304-313, 2019

158
Pereira D.S.M.,Cardoso B.D.,Rodrigues A.R.O.,Amorim C.O.,Amaral V.S.,Almeida B.G.,Queiroz M.J.R.P.,Martinho O.,Baltazar F.,Calhelha R.C.,Ferreira I.C.F.R.,Coutinho P.J.G.,Castanheira E.M.S.
Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
Pharmaceutics, 11, , 2019

159
Caleja C.,Finimundy T.C.,Pereira C.,Barros L.,Calhelha R.C.,Sokovic M.,Ivanov M.,Carvalho A.M.,Rosa E.,Ferreira I.C.F.R.
Challenges of traditional herbal teas: Plant infusions and their mixtures with bioactive properties
Food and Function, 10, 5939-5951, 2019

160
Rached W.,Barros L.,Ziani B.E.C.,Bennaceur M.,Calhelha R.C.,Heleno S.A.,Alves M.J.,Marouf A.,Ferreira I.C.F.R.
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.
Food and Function, 10, 5898-5909, 2019

161
da Silva S.C.,Fernandes I.P.,Barros L.,Fernandes Â.,José Alves M.,Calhelha R.C.,Pereira C.,Barreira J.C.M.,Manrique Y.,Colla E.,Ferreira I.C.F.R.,Filomena Barreiro M.
Spray-dried Spirulina platensis as an effective ingredient to improve yogurt formulations: Testing different encapsulating solutions
Journal of Functional Foods, 60, , 2019

162
Afonso A.F.,Pereira O.R.,Fernandes Â.S.F.,Calhelha R.C.,Silva A.M.S.,Ferreira I.C.F.R.,Cardoso S.M.
The health-benefits and phytochemical profile of salvia apiana and salvia farinacea var. Victoria blue decoctions
Antioxidants, 8, , 2019

163
Falcão S.I.,Calhelha R.C.,Touzani S.,Lyoussi B.,Ferreira I.C.F.R.,Vilas-Boas M.
In vitro interactions of moroccan propolis phytochemical’s on human tumor cell lines and anti-inflammatory properties
Biomolecules, 9, , 2019

164
Vieira V.,Pereira C.,Pires T.C.S.P.,Calhelha R.C.,Alves M.J.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal
Industrial Crops and Products, 134, 347-355, 2019

165
Alonso-Esteban J.I.,Pinela J.,Barros L.,Ćirić A.,Soković M.,Calhelha R.C.,Torija-Isasa E.,de Cortes Sánchez-Mata M.,Ferreira I.C.F.R.
Phenolic composition and antioxidant, antimicrobial and cytotoxic properties of hop (Humulus lupulus L.) Seeds
Industrial Crops and Products, 134, 154-159, 2019

166
Da Silva L.P.,Pereira E.,Prieto M.A.,Simal-Gandara J.,Pires T.C.S.P.,Alves M.J.,Calhelha R.,Barros L.,Ferreira I.C.F.R.
Rubus ulmifolius Schott as a Novel Source of Food Colorant: Extraction optimization of coloring pigments and incorporation in a bakery product
Molecules, 24, , 2019

167
Fernandes F.,Pereira E.,Círić A.,Soković M.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Ocimum basilicum var. Purpurascens leaves (red rubin basil): A source of bioactive compounds and natural pigments for the food industry
Food and Function, 10, 3161-3171, 2019

168
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity
Microchemical Journal, 147, 469-477, 2019

169
Castanho A.,Lageiro M.,Calhelha R.C.,Ferreira I.C.F.R.,Sokovic M.,Cunha L.M.,Brites C.
Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties
Food and Function, 10, 2382-2389, 2019

170
Chahdoura H.,Barreira J.C.M.,Barros L.,Dias M.I.,Calhelha R.C.,Flamini G.,Soković M.,Achour L.,Ferreira I.C.F.R.
Bioactivity, hydrophilic, lipophilic and volatile compounds in pulps and skins of Opuntia macrorhiza and Opuntia microdasys fruits
LWT, 105, 57-65, 2019

171
Jabeur I.,Pereira E.,Caleja C.,Calhelha R.C.,Soković M.,Catarino L.,Barros L.,Ferreira I.C.F.R.
Exploring the chemical and bioactive properties of: Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa)
Food and Function, 10, 2234-2243, 2019

172
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds
Journal of Functional Foods, 55, 325-332, 2019

173
Pinho E.,Calhelha R.C.,Ferreira I.C.F.R.,Soares G.
Cotton-hydrogel composite for improved wound healing: Antimicrobial activity and anti-inflammatory evaluation—Part 2
Polymers for Advanced Technologies, 30, 863-871, 2019

174
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Amantagula Fruit (Carissa macrocarpa (Eckl.) A.DC.): Nutritional and Phytochemical Characterization
Plant Foods for Human Nutrition, 74, 76-82, 2019

175
Silva de Sá I.,Peron A.P.,Leimann F.V.,Bressan G.N.,Krum B.N.,Fachinetto R.,Pinela J.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Gonçalves O.H.,Ineu R.P.
In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions
Food and Chemical Toxicology, 125, 29-37, 2019

176
López C.J.,Caleja C.,Prieto M.A.,Sokovic M.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes
Food Chemistry, 275, 426-438, 2019

177
Fernandes F.,Pereira E.,Prieto M.A.,Calhelha R.C.,Ćirić A.,Soković M.,Simal-Gandara J.,Barros L.,Ferreira I.C.F.R.
Optimization of the Extraction Process to Obtain a Colorant Ingredient from Leaves of Ocimum basilicum var. Purpurascens
Molecules, 24, , 2019

178
Dos Santos P.D.F.,Francisco C.R.L.,Coqueiro A.,Leimann F.V.,Pinela J.,Calhelha R.C.,Porto Ineu R.,Ferreira I.C.F.R.,Bona E.,Gonçalves O.H.
The nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Food and Function, 10, 573-582, 2019

179
Ziani B.E.C.,Rached W.,Bachari K.,Alves M.J.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck
Journal of Functional Foods, 53, 237-247, 2019

180
Lockowandt L.,Pinela J.,Roriz C.L.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Barros L.,Bredol M.,Ferreira I.C.F.R.
Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part
Industrial Crops and Products, 128, 496-503, 2019

181
Gonçalves G.A.,Corrêa R.C.G.,Barros L.,Dias M.I.,Calhelha R.C.,Correa V.G.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid
Food Chemistry, 271, 393-400, 2019

182
Da Silva R.F.R.,Barreira J.C.M.,Heleno S.A.,Barros L.,Calhelha R.C.,Ferreira I.C.F.R.
Anthocyanin profile of elderberry juice: A natural-based bioactive colouring ingredient with potential food application
Molecules, 24, , 2019

183
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers
Molecules, 24, , 2019

184
Mandim F.,Graça V.C.,Calhelha R.C.,Machado I.L.F.,Ferreira L.F.V.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of new iodinated aminosquaraines as potential sensitizers for photodynamic therapy
Molecules, 24, , 2019

185
Magalhães Á.F.,Graça V.C.,Calhelha R.C.,Ferreira Machado I.L.,Vieira Ferreira L.F.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines
Photochemical and Photobiological Sciences, 18, 336-342, 2019

186
Mandim F.,Barros L.,Calhelha R.C.,Abreu R.M.V.,Pinela J.,Alves M.J.,Heleno S.,Santos P.F.,Ferreira I.C.F.R.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

187
Rodrigues R.O.,Baldi G.,Doumett S.,Garcia-Hevia L.,Gallo J.,Bañobre-López M.,Dražić G.,Calhelha R.C.,Ferreira I.C.F.R.,Lima R.,Gomes H.T.,Silva A.M.T.
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery
Materials Science and Engineering C, 93, 206-217, 2018

188
Petropoulos S.A.,Fernandes Â.,Calhelha R.C.,Danalatos N.,Barros L.,Ferreira I.C.F.R.
How extraction method affects yield, fatty acids composition and bioactive properties of cardoon seed oil?
Industrial Crops and Products, 124, 459-465, 2018

189
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile
Industrial Crops and Products, 124, 44-52, 2018

190
Zan R.A.,Fernandes Â.,Jedoz S.,Oludemi T.,Calhelha R.C.,Pires T.C.S.P.,Alves M.J.,Martins R.C.C.,Barros L.,Ferreira I.C.F.R.
Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
Food and Function, 9, 5621-5628, 2018

191
Pires T.C.S.P.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Santos-Buelga C.,Ferreira I.C.F.R.
Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits
Industrial Crops and Products, 122, 574-581, 2018

192
Pereira E.,Pimenta A.I.,Barros L.,Calhelha R.C.,Antonio A.L.,Cabo Verde S.,Ferreira I.C.F.R.
Effects of gamma radiation on the bioactivity of medicinal and aromatic plants: Mentha × piperita L., Thymus vulgaris L. and Aloysia citrodora Paláu as case studies
Food and Function, 9, 5150-5161, 2018

193
Almeida H.H.S.,Barros L.,Barreira J.C.M.,Calhelha R.C.,Heleno S.A.,Sayer C.,Miranda C.G.,Leimann F.V.,Barreiro M.F.,Ferreira I.C.F.R.
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)
Food Chemistry, 261, 224-232, 2018

194
Ghouti D.,Rached W.,Abdallah M.,Pires T.C.S.P.,Calhelha R.C.,Alves M.J.,Abderrahmane L.H.,Barros L.,Ferreira I.C.F.R.
Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria
Food and Function, 9, 4664-4672, 2018

195
Santos K.S.,Barbosa A.M.,Freitas V.,Muniz A.V.C.S.,Mendonça M.C.,Calhelha R.C.,Ferreira I.C.F.R.,Franceschi E.,Padilha F.F.,Oliveira M.B.P.P.,Dariva C.
Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction
Pharmaceuticals, 11, , 2018

196
Halla N.,Heleno S.A.,Costa P.,Fernandes I.P.,Calhelha R.C.,Boucherit K.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Chemical profile and bioactive properties of the essential oil isolated from Ammodaucus leucotrichus fruits growing in Sahara and its evaluation as a cosmeceutical ingredient
Industrial Crops and Products, 119, 249-254, 2018

197
Nenadić M.,Soković M.,Calhelha R.C.,Ferreira I.C.F.R.,Ćirić A.,Vesović N.,Ćurčić S.
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
Biologia, 73, 787-792, 2018

198
Kungel P.T.A.N.,Correa V.G.,Corrêa R.C.G.,Peralta R.A.,Soković M.,Calhelha R.C.,Bracht A.,Ferreira I.C.F.R.,Peralta R.M.
Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)
International Journal of Biological Macromolecules, 114, 1161-1167, 2018

199
Rocha F.,Yumi Sugahara L.,Leimann F.V.,De Oliveira S.M.,Da Silva Brum E.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Porto Ineu R.,Gonçalves O.H.
Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties
Food and Function, 9, 3698-3706, 2018

200
Peixoto C.M.,Dias M.I.,Alves M.J.,Calhelha R.C.,Barros L.,Pinho S.P.,Ferreira I.C.F.R.
Grape pomace as a source of phenolic compounds and diverse bioactive properties
Food Chemistry, 253, 132-138, 2018

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