MOUNTAIN
RESEARCH
CENTER
Polytechnic Institute
of Bragança
FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.
Clementina Maria Moreira dos Santos
Auxiliary ProfessorGroup: Sustainable Processes and Products
Phone: 273303308
E-mail: clems@ipb.pt
ORCID: 0000-0003-4380-7990
Scopus Author ID: 7201458663
Career
- Since 2010: Auxiliary Professor, Polytechnic Institute of Bragança, Bragança
- 2000 - 2010: Assistant, Polytechnic Institute of Bragança, Bragança, Portugal
Qualifications
- 2007 - in Chemistry, Universidade de Aveiro, Portugal
- 2000 - in Chemistry of Natural Products and Foodstuffs, Universidade de Aveiro, Portugal
- 1991 - in Food Chemistry, Universidade de Aveiro, Portugal
Interests
- Organic chemistry
- Synthesis of heterocyclic compounds, namely chromone- and xanthone-type derivatives
- Structural characterization of compounds by NMR and MS
- Evaluation of the antioxidant and anti-inflammatory activities using chemical and enzymatic assays
Total results: 57
1
Santos C.M.M.,Proença C.,Freitas M.,Araújo A.N.,Silva A.M.S.,Fernandes E.
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus
Medicinal Chemistry Research, , 2024
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus
Medicinal Chemistry Research, , 2024
2
Santos C.M.M.,Silva A.M.S.
Six-membered ring systems: With O and/or S atoms
Progress in Heterocyclic Chemistry, 35, 493-568, 2024
Six-membered ring systems: With O and/or S atoms
Progress in Heterocyclic Chemistry, 35, 493-568, 2024
3
Santos C.M.M.,Silva A.M.S.
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 34, 487-557, 2023
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 34, 487-557, 2023
4
Santos C.M.M.,Proença C.,Freitas M.,Araújo A.N.,Silva A.M.S.,Fernandes E.
Inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by hydroxylated xanthones
Food and Function, 13, 7930-7941, 2022
Inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by hydroxylated xanthones
Food and Function, 13, 7930-7941, 2022
5
Albuquerque H.M.T.,Nunes da Silva R.,Pereira M.,Maia A.,Guieu S.,Soares A.R.,Santos C.M.M.,Vieira S.I.,Silva A.M.S.
Steroid-Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes
ACS Medicinal Chemistry Letters, 13, 443-448, 2022
Steroid-Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes
ACS Medicinal Chemistry Letters, 13, 443-448, 2022
6
Silva V.L.M.,Pinto D.C.G.A.,Santos C.M.M.,Rocha D.H.A.
Quinolinones and Related Systems (Update 2022)
Science of Synthesis, 2022, 183-442, 2022
Quinolinones and Related Systems (Update 2022)
Science of Synthesis, 2022, 183-442, 2022
7
Albuquerque H.M.T.,Santos C.M.M.,Silva A.M.S.
Cholesterol chemistry and laboratory synthesis
Cholesterol: From Chemistry and Biophysics to the Clinic, 3-24, 2022
Cholesterol chemistry and laboratory synthesis
Cholesterol: From Chemistry and Biophysics to the Clinic, 3-24, 2022
8
Santos C.M.M.,Silva A.M.S.
Recent advances in the synthesis of 4H-chromen-4-ones (2012 − 2021)
Advances in Heterocyclic Chemistry, 138, 159-241, 2022
Recent advances in the synthesis of 4H-chromen-4-ones (2012 − 2021)
Advances in Heterocyclic Chemistry, 138, 159-241, 2022
9
Santos C.M.M.,Silva A.M.S.
Eight-Membered Rings With One Oxygen Atom
Comprehensive Heterocyclic Chemistry IV, 44-84, 2021
Eight-Membered Rings With One Oxygen Atom
Comprehensive Heterocyclic Chemistry IV, 44-84, 2021
10
Santos C.M.M.,Silva A.M.S.
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 33, 473-532, 2021
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 33, 473-532, 2021
11
Santos C.M.M.,Silva A.M.S.
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 32, 501-563, 2021
Six-membered ring systems: with O and/or S atoms
Progress in Heterocyclic Chemistry, 32, 501-563, 2021
12
13
Santos C.M.M.,Silva A.M.S.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 31, 533-595, 2020
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 31, 533-595, 2020
14
Rocha S.,Sousa A.,Ribeiro D.,Correia C.M.,Silva V.L.M.,Santos C.M.M.,Silva A.M.S.,Araújo A.N.,Fernandes E.,Freitas M.
A study towards drug discovery for the management of type 2 diabetes: Mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives
Food and Function, 10, 5510-5520, 2019
A study towards drug discovery for the management of type 2 diabetes: Mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives
Food and Function, 10, 5510-5520, 2019
15
Rocha S.,Sousa A.,Ribeiro D.,Correia C.M.,Silva V.L.M.,Santos C.M.M.,Silva A.M.S.,Araújo A.N.,Fernandes E.,Freitas M.
Correction: A study towards drug discovery for the management of type 2 diabetes: Mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives (Food and Function (2019) DOI: 10.1039/c9fo01298b)
Food and Function, 10, 6203, 2019
Correction: A study towards drug discovery for the management of type 2 diabetes: Mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives (Food and Function (2019) DOI: 10.1039/c9fo01298b)
Food and Function, 10, 6203, 2019
16
Albuquerque H.M.T.,Santos C.M.M.,Silva A.M.S.
Cholesterol-based compounds: Recent advances in synthesis and applications
Molecules, 24, , 2019
Cholesterol-based compounds: Recent advances in synthesis and applications
Molecules, 24, , 2019
17
Santos C.M.M.,Freitas M.,Fernandes E.
A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
European Journal of Medicinal Chemistry, 157, 1460-1479, 2018
A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
European Journal of Medicinal Chemistry, 157, 1460-1479, 2018
18
Santos C.,Silva A.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 30, 427-491, 2018
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 30, 427-491, 2018
19
Albuquerque H.M.T.,Santos C.M.M.,Cavaleiro J.A.S.,Silva A.M.S.
First intramolecular Diels-Alder reactions using chromone derivatives: Synthesis of chromeno[3,4-: B] xanthones and 2-(benzo [c] chromenyl)chromones
New Journal of Chemistry, 42, 4251-4260, 2018
First intramolecular Diels-Alder reactions using chromone derivatives: Synthesis of chromeno[3,4-: B] xanthones and 2-(benzo [c] chromenyl)chromones
New Journal of Chemistry, 42, 4251-4260, 2018
20
21
Albuquerque H.,Santos C.,Balanay M.,Cavaleiro J.,Silva A.
1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones
European Journal of Organic Chemistry, 2017, 5293-5305, 2017
1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones
European Journal of Organic Chemistry, 2017, 5293-5305, 2017
22
Santos C.M.M.,Silva A.M.S.
An Overview of 2-Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties
European Journal of Organic Chemistry, 2017, 3115-3133, 2017
An Overview of 2-Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties
European Journal of Organic Chemistry, 2017, 3115-3133, 2017
23
Santos C.M.M.,Ribeiro D.,Silva A.M.S.,Fernandes E.
2,3-Diarylxanthones as potential inhibitors of arachidonic acid metabolic pathways
Inflammation, 40, 956-964, 2017
2,3-Diarylxanthones as potential inhibitors of arachidonic acid metabolic pathways
Inflammation, 40, 956-964, 2017
24
Albuquerque H.,Santos C.,Lima C.,Santos L.,Cavaleiro J.,Silva A.
2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies
European Journal of Organic Chemistry, 2017, 87-101, 2017
2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies
European Journal of Organic Chemistry, 2017, 87-101, 2017
25
Santos C.,Silva A.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 29, 519-578, 2017
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 29, 519-578, 2017
26
Silva E.,Barros C.,Santos C.,Barros A.,Domingues M.,Silva A.
Characterization of 2,3-diarylxanthones by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties
Rapid communications in mass spectrometry : RCM, 30, 2228-2236, 2016
Characterization of 2,3-diarylxanthones by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties
Rapid communications in mass spectrometry : RCM, 30, 2228-2236, 2016
27
Proença C.,Albuquerque H.M.T.,Ribeiro D.,Freitas M.,Santos C.M.M.,Silva A.M.S.,Fernandes E.
Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities
European Journal of Medicinal Chemistry, 115, 381-392, 2016
Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities
European Journal of Medicinal Chemistry, 115, 381-392, 2016
28
Santos C.M.M.,Pinto D.C.G.A.,Silva V.L.M.,Silva A.M.S.
Arylxanthones and arylacridones: A synthetic overview
Pure and Applied Chemistry, 88, 579-594, 2016
Arylxanthones and arylacridones: A synthetic overview
Pure and Applied Chemistry, 88, 579-594, 2016
29
Santos C.,Silva A.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 28, 523-578, 2016
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 28, 523-578, 2016
30
Albuquerque H.M.T.,Santos C.M.M.,Cavaleiro J.A.S.,Silva A.M.S.
(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads
European Journal of Organic Chemistry, 2015, 4732-4743, 2015
(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads
European Journal of Organic Chemistry, 2015, 4732-4743, 2015
31
Gomes A.,Capela J.P.,Ribeiro D.,Freitas M.,Silva A.M.S.,Pinto D.C.G.A.,Santos C.M.M.,Cavaleiro J.A.S.,Lima J.L.F.C.,Fernandes E.
Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones
Medicinal Chemistry, 11, 560-566, 2015
Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones
Medicinal Chemistry, 11, 560-566, 2015
32
Santos C.,Silva A.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 27, 465-529, 2015
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 27, 465-529, 2015
33
Albuquerque H.M.T.,Santos C.M.M.,Cavaleiro J.A.S.,Silva A.M.S.
Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocycles
Current Organic Chemistry, 18, 2750-2775, 2014
Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocycles
Current Organic Chemistry, 18, 2750-2775, 2014
34
Santos C.,Silva A.
Six-membered ring systems: With O and/or S atoms
Progress in Heterocyclic Chemistry, 26, 463-520, 2014
Six-membered ring systems: With O and/or S atoms
Progress in Heterocyclic Chemistry, 26, 463-520, 2014
35
Santos C.,Silva A.
Nuclear magnetic resonance spectroscopy for structural characterization of bioactive compounds
Comprehensive Analytical Chemistry, 65, 149-191, 2014
Nuclear magnetic resonance spectroscopy for structural characterization of bioactive compounds
Comprehensive Analytical Chemistry, 65, 149-191, 2014
36
Tomé S.,Silva A.,Santos C.
Synthesis and transformation of halochromones
Current Organic Synthesis, 11, 317-341, 2014
Synthesis and transformation of halochromones
Current Organic Synthesis, 11, 317-341, 2014
37
Santos C.M.M.,Garcia M.B.Q.,Silva A.M.S.,Santus R.,Morlière P.,Fernandes E.
Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry
Tetrahedron Letters, 54, 85-90, 2013
Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry
Tetrahedron Letters, 54, 85-90, 2013
38
Santos C.M.M.,Silva A.M.S.
Six-membered ring systems. With O and/or S atoms.
Progress in Heterocyclic Chemistry, 25, 409-453, 2013
Six-membered ring systems. With O and/or S atoms.
Progress in Heterocyclic Chemistry, 25, 409-453, 2013
39
Patoilo D.,Silva A.,Pinto D.,Santos C.,Tomé A.,Cavaleiro J.
Tetrahydroquinazoline-substituted chromones from Diels-Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane
Tetrahedron Letters, 53, 2722-2725, 2012
Tetrahydroquinazoline-substituted chromones from Diels-Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane
Tetrahedron Letters, 53, 2722-2725, 2012
40
Santos C.,Silva A.,Jeko J.,Lévai A.
Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine
Arkivoc, 2012, 265-281, 2012
Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine
Arkivoc, 2012, 265-281, 2012
41
Morlière P.,Patterson L.K.,Santos C.M.M.,Silva A.M.S.,Mazière J.C.,Filipe P.,Gomes A.,Fernandes E.,Garcia M.B.Q.,Santus R.
The dependence of α-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment
Organic and Biomolecular Chemistry, 10, 2068-2076, 2012
The dependence of α-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment
Organic and Biomolecular Chemistry, 10, 2068-2076, 2012
42
Santos C.,Silva A.
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 24, 443-492, 2012
Six-Membered Ring Systems: With O and/or S Atoms
Progress in Heterocyclic Chemistry, 24, 443-492, 2012
43
Santos C.M.M.,Silva A.M.S.,Filipe P.,Santus R.,Patterson L.K.,Mazière J.C.,Cavaleiro J.A.S.,Morlière P.
Structure-activity relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for antioxidant activity in biological systems
Organic and Biomolecular Chemistry, 9, 3965-3974, 2011
Structure-activity relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for antioxidant activity in biological systems
Organic and Biomolecular Chemistry, 9, 3965-3974, 2011
44
Esteves C.,Santos C.,Brito C.,Silva A.,Cavaleiro J.
Synthesis of novel 1-aryl-9 H -xanthen-9-ones
Synlett, 1403-1406, 2011
Synthesis of novel 1-aryl-9 H -xanthen-9-ones
Synlett, 1403-1406, 2011
45
Santos C.M.M.,Freitas M.,Ribeiro D.,Gomes A.,Silva A.M.S.,Cavaleiro J.A.S.,Fernandes E.
2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study
Bioorganic and Medicinal Chemistry, 18, 6776-6784, 2010
2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study
Bioorganic and Medicinal Chemistry, 18, 6776-6784, 2010
46
Gomes A.,Fernandes E.,Silva A.M.S.,Pinto D.C.G.A.,Santos C.M.M.,Cavaleiro J.A.S.,Lima J.L.F.C.
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways
Biochemical Pharmacology, 78, 171-177, 2009
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways
Biochemical Pharmacology, 78, 171-177, 2009
47
Santos C.M.M.,Silva A.M.S.,Cavaleiro J.A.S.
Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones
European Journal of Organic Chemistry, 2642-2660, 2009
Efficient syntheses of new polyhydroxylated 2,3-diaryl-9H-xanthen-9-ones
European Journal of Organic Chemistry, 2642-2660, 2009
48
Ĺvai A.,Silva A.M.S.,Santos C.M.M.,Cavaleiro J.A.S.,Jek J.
Dimethyldioxirane oxidation of exocyclic (E,E)-cinnamylideneketones
Australian Journal of Chemistry, 62, 82-89, 2009
Dimethyldioxirane oxidation of exocyclic (E,E)-cinnamylideneketones
Australian Journal of Chemistry, 62, 82-89, 2009
49
Gomes A.,Fernandes E.,Garcia M.B.Q.,Silva A.M.S.,Pinto D.C.G.A.,Santos C.M.M.,Cavaleiro J.A.S.,Lima J.L.F.C.
Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity
Bioorganic and Medicinal Chemistry, 16, 7939-7943, 2008
Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity
Bioorganic and Medicinal Chemistry, 16, 7939-7943, 2008
50
Santos C.,Silva A.,Cavaleiro J.
A novel and efficient route for the synthesis of hydroxylated 2,3-diarylxanthones
Synlett, 3113-3116, 2007
A novel and efficient route for the synthesis of hydroxylated 2,3-diarylxanthones
Synlett, 3113-3116, 2007
51
Gomes A.,Fernandes E.,Silva A.M.S.,Santos C.M.M.,Pinto D.C.G.A.,Cavaleiro J.A.S.,Lima J.L.F.C.
2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species
Bioorganic and Medicinal Chemistry, 15, 6027-6036, 2007
2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species
Bioorganic and Medicinal Chemistry, 15, 6027-6036, 2007
52
Santos C.,Silva A.,Cavaleiro J.,Lévai A.,Patonay T.
Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst
European Journal of Organic Chemistry, 2877-2887, 2007
Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst
European Journal of Organic Chemistry, 2877-2887, 2007
53
Santos C.M.M.,Silva A.M.S.,Cavaleiro J.A.S.,Patonay T.,Lévai A.
Epoxidation studies of 2-styrylchromones using Jacobsen's catalyst and hydrogen peroxide and iodosylbenzene as oxidants
Journal of Heterocyclic Chemistry, 43, 1319-1326, 2006
Epoxidation studies of 2-styrylchromones using Jacobsen's catalyst and hydrogen peroxide and iodosylbenzene as oxidants
Journal of Heterocyclic Chemistry, 43, 1319-1326, 2006
54
55
Santos C.,Silva A.,Cavaleiro J.
Synthesis of New Hydroxy-2-styrylchromones
European Journal of Organic Chemistry, 4575-4585, 2003
Synthesis of New Hydroxy-2-styrylchromones
European Journal of Organic Chemistry, 4575-4585, 2003
56
Fernandes E.,Carvalho M.,Carvalho F.,Silva A.,Santos C.,Pinto D.,Cavaleiro J.,Maria D.
Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes
Archives of Toxicology, 77, 500-505, 2003
Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes
Archives of Toxicology, 77, 500-505, 2003
57
Fernandes E.,Carvalho F.,Silva A.,Santos C.,Pinto D.,Cavaleiro J.,Bastos M.
2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study
Journal of Enzyme Inhibition and Medicinal Chemistry, 17, 45-48, 2002
2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study
Journal of Enzyme Inhibition and Medicinal Chemistry, 17, 45-48, 2002