MOUNTAIN
RESEARCH
CENTER

Polytechnic Institute
of Bragança

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CIMO

CIMO - Mountain Research Center. See video HERE

FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.

Rui Miguel Vaz de Abreu

Adjunct Professor
Group: Sustainable Processes and Products
Phone: 273303244
E-mail: ruiabreu@ipb.pt
ORCID: 0000-0002-7745-8015
Scopus Author ID: 7003290613

Career

  • Since 2011: Auxiliary Professor at the School of Agriculture of the Polytechnic Institute of Bragança (ESA-IPB), Portugal
  • 1998 - 2011: Assistant Professor at the School of Agriculture of the Polytechnic Institute of Bragança (ESA-IPB), Portugal

Qualifications

  • 2011 - PhD. in Comparative and Molecular Genetics, University of Trás-os-Montes and Alto Douro (UTAD), Portugal
  • 2001 - MSc. in Molecular and Celular Biology, University of Coimbra (UC), Portugal
  • 1997 - Graduation in Biochemistry, University of Coimbra (UC), Portugal

Interests

  • Biological activity evaluation of natural/synthetic compounds using in vitro cell-based and enzymatic assays
  • Application and software development of pharmacoinformatic in silico techniques including: molecular docking, MD simulations and QSAR analysis

Projects:

TRANSCOLAB PLUS - Laboratorio Colaborativo Transfronterizo para la transicion verde del sector Agroalimentario y Agroindustrial
Funding body: POCTEP 2021-2027
Reference: 0112_TRANSCOLAB_PLUS_2_P
Principal Investigator:Barros, Lillian
Start: 2023-10-01
End: 2026-12-31
NET4FOOD - Red de INVESTIGACION e innovacion para el sector alimentario en la region transfronteriza
Funding body: POCTEP 2021-2027
Reference: 0033_NET4FOOD_1_P
Principal Investigator:Barros, Lillian
Start: 2023-04-01
End: 2025-12-31
BEONNAT - Innovative value chains from tree & shrub species grown in marginal lands as a source of biomass for bio-based industries
Funding body: HORIZON 2020
Reference: BBI-2019-SO1-R1 - 887917 – BEONNAT
Principal Investigator:Barros, Lillian
Start: 2020-07-01
End: 2025-06-30
PulpIng - Development of Pumpking Pulp Formulations using a Sustainable Integrated Strategy
Funding body: PRIMA
Reference: PRIMA/0007/2019
Principal Investigator:Barros, Lillian
Start: 2020-09-01
End: 2024-08-31
Aquavitae - Thermal water as a source of life and health
Funding body: Promove LA CAIXA
Reference: PD20-00003
Principal Investigator:Barros, Lillian
Start: 2021-09-01
End: 2024-05-31
WASTESILK - Silk Sericin as an industrial wastewater with valuable biomedical potential
Funding body: FCT
Reference: PTDC/BTA-BTA/0696/2020
Principal Investigator:Barros, Lillian
Start: 2021-03-29
End: 2024-03-28
HealthyPETFOOD - Formulações PetFood para promoção da saúde e qualidade de vida
Funding body: PORTUGAL 2020
Reference: POCI-01-0247-FEDER-047073
Principal Investigator:Barros, Lillian
Start: 2020-07-01
End: 2023-06-30
OliveBIOextract - Aproveitamento sustentável do bagaço de azeitona numa cadeia de valorização integrada utilizando processos inovadores
Funding body: NORTE 2020
Reference: NORTE-01-0247-FEDER-049865
Principal Investigator:Barros, Lillian
Start: 2021-02-01
End: 2023-06-30
VALORNATURAL - Valorização de Recursos Naturais através da Extração de Ingredientes de Elevado Valor Acrescentado para Aplicações na Indústria Alimentar
Funding body: NORTE 2020
Reference: NORTE-01-0247-FEDER-024479
Principal Investigator:Barros, Lillian
Start: 2018-09-01
End: 2022-08-31
TRANSCoLAB - Laboratorio Colaborativo Transfronterizo para la sostenibilidad y innovación del sector Agroalimentario y Agroindustrial
Funding body: POCTEP 2014-2020
Reference: 0612_TRANS_CO_LAB_2_P
Principal Investigator:Barros, Lillian
Start: 2018-01-01
End: 2022-04-05
MAGLIDUO - MAGnetoLIposomes for DUal cancer therapy
Funding body: PORTUGAL 2020
Reference: POCI-01-0145-FEDER-028020
Principal Investigator:Barros, Lillian
Start: 2018-07-01
End: 2021-12-31
PlantCovid - Aplicações de extratos de plantas com ação dirigida ao SARS-CoV-2
Funding body: NORTE 2020
Reference: NORTE-01-02B/-FEDER-054870
Principal Investigator:Barros, Lillian
Start: 2020-07-14
End: 2021-12-31
AROMAP - Preservation of aromatic condiment plants
Funding body: PRODER - Medida 4.1
Reference:
Principal Investigator:Ferreira, Isabel C.F.R.; Ferreira, I. C.F.R.; Ferreira, I.C.F.R.
Start: 2014-05-01
End: 2016-10-31
PlantLact - New functional dairy products without synthetic preservatives
Funding body: PRODER - Medida 4.1
Reference:
Principal Investigator:Ferreira, Isabel C.F.R.; Ferreira, I. C.F.R.; Ferreira, I.C.F.R.
Start: 2014-01-01
End: 2015-12-31
- Bioactive properties of wild edible mushroomes
Funding body: FCT
Reference: POCI/AGR/56661/2004 and PPCDT/AGR/56661/2004
Principal Investigator:Ferreira, Isabel C.F.R.; Ferreira, I. C.F.R.; Ferreira, I.C.F.R.
Start: 2005-10-01
End: 2008-09-30
- Estratégias para a minimização da Safra e contra safra do olival
Funding body: AGRO - Programa Operacional Agricultura e Desenvolvimento Rural
Reference:
Principal Investigator:Rodrigues, M. Ângelo; Rodrigues, Manuel Ângelo
Start: 2003-01-01
End: 2007-01-01

Total results: 46
1
Leimann F.V.,de Souza L.B.,de Oliveira B.P.M.,Rossi B.F.,da Silva P.S.,Shiraishi C.S.H.,Kaplum V.,Abreu R.M.,Pereira C.,Barros L.,Peron A.P.,Ineu R.P.,Oechsler B.F.,Sayer C.,de Araújo P.H.H.,Gonçalves O.H.
Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity
Food Research International, 173, , 2023

2
Serrano C.,Sapata M.,Oliveira M.C.,Soares A.,Pereira C.,Abreu R.M.V.,Barros L.
Encapsulation of Sorghum Leaf Red Dye: Biological and Physicochemical Properties and Effect on Stability
Foods, 12, , 2023

3
Shiraishi C.S.H.,Zbiss Y.,Roriz C.L.,Dias M.I.,Prieto M.A.,Calhelha R.C.,Alves M.J.,Heleno S.A.,da Cunha Mendes V.,Carocho M.,Abreu R.M.V.,Barros L.
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes, 11, , 2023

4
Calhelha R.C.,Shiraishi C.S.H.,Ribeiro L.,Carocho M.,Abreu R.,Coutinho P.,Barros L.,Vaz J.,Ferreira I.C.F.R.
New trends from fungi secondary metabolism in the pharmaceutical industry
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 823-850, 2023

5
Novais C.,Molina A.K.,Abreu R.M.V.,Santo-Buelga C.,Ferreira I.C.F.R.,Pereira C.,Barros L.
Natural Food Colorants and Preservatives: A Review, a Demand, and a Challenge
Journal of Agricultural and Food Chemistry, 70, 2789-2805, 2022

6
Rodrigues M.J.,Castañeda-Loaiza V.,Monteiro I.,Pinela J.,Barros L.,Abreu R.M.V.,Oliveira M.C.,Reis C.,Soares F.,Pousão-Ferreira P.,Pereira C.G.,Custódio L.
Metabolomic profile and biological properties of sea lavender (Limonium algarvense erben) plants cultivated with aquaculture wastewaters: Implications for its use in herbal formulations and food additives
Foods, 10, , 2021

7
De Oliveira A.,Moreira T.F.M.,Pepinelli A.L.S.,Costa L.G.M.A.,Leal L.E.,Da Silva T.B.V.,Gonçalves O.H.,Porto Ineu R.,Dias M.I.,Barros L.,Abreu R.M.V.,Ferreira I.C.F.R.,Bracht L.,Leimann F.V.
Bioactivity screening of pinhão (: Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: The inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities
Food and Function, 12, 9820-9828, 2021

8
Cardoso R.V.C.,Fernandes Â.,Barreira J.C.M.,Abreu R.M.V.,Mandim F.,Gonzaléz-Paramás A.M.,Ferreira I.C.F.R.,Barros L.
A case study on surplus mushrooms production: Extraction and recovery of vitamin d2
Agriculture (Switzerland), 11, , 2021

9
Pantuzza Silva G.F.,Pereira E.,Melgar B.,Stojković D.,Sokovic M.,Calhelha R.C.,Pereira C.,Abreu R.M.V.,Ferreira I.C.F.R.,Barros L.
Eggplant fruit (Solanum melongena l.) and bio‐residues as a source of nutrients, bioactive compounds, and food colorants, using innovative food technologies
Applied Sciences (Switzerland), 11, 1-24, 2021

10
Rocha R.,Pinela J.,Abreu R.M.V.,Añibarro-Ortega M.,Pires T.C.S.P.,Saldanha A.L.,Alves M.J.,Nogueira A.,Ferreira I.C.F.R.,Barros L.
Extraction of anthocyanins from red raspberry for natural food colorants development: Processes optimization and in vitro bioactivity
Processes, 8, 1-19, 2020

11
Ziani B.E.C.,Carocho M.,Abreu R.M.V.,Bachari K.,Alves M.J.,Calhelha R.C.,Talhi O.,Barros L.,Ferreira I.C.F.R.
Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts
Food Bioscience, 36, , 2020

12
Albuquerque B.R.,Pereira C.,Calhelha R.C.,José Alves M.,Abreu R.M.V.,Barros L.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties
Food Chemistry, 309, , 2020

13
Vieira V.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Coutinho J.A.P.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals
Food and Chemical Toxicology, 137, , 2020

14
Palmeira L.,Pereira C.,Dias M.I.,Abreu R.M.V.,Corrêa R.C.G.,Pires T.C.S.P.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
Nutritional, chemical and bioactive profiles of different parts of a Portuguese common fig (Ficus carica L.) variety
Food Research International, 126, , 2019

15
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest
Food Chemistry, 294, 302-308, 2019

16
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds
Journal of Functional Foods, 55, 325-332, 2019

17
Mosbah H.,Chahdoura H.,Mannai A.,Snoussi M.,Aouadi K.,Abreu R.M.V.,Bouslama A.,Achour L.,Selmi B.
Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies
Applied Biochemistry and Biotechnology, 187, 1113-1130, 2019

18
Lockowandt L.,Pinela J.,Roriz C.L.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Barros L.,Bredol M.,Ferreira I.C.F.R.
Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part
Industrial Crops and Products, 128, 496-503, 2019

19
Mandim F.,Barros L.,Calhelha R.C.,Abreu R.M.V.,Pinela J.,Alves M.J.,Heleno S.,Santos P.F.,Ferreira I.C.F.R.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

20
Finimundy T.C.,Barros L.,Calhelha R.C.,Alves M.J.,Prieto M.A.,Abreu R.M.V.,Dillon A.J.P.,Henriques J.A.P.,Roesch-Ely M.,Ferreira I.C.F.R.
Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds
Food Chemistry, 245, 150-158, 2018

21
Ribeiro A.,Abreu R.M.V.,Dias M.M.,Barreiro M.F.,Ferreira I.C.F.R.
Antiangiogenic compounds: well-established drugs versus emerging natural molecules
Cancer Letters, 415, 86-105, 2018

22
Finimundy T.C.,Abreu R.M.V.,Bonetto N.,Scariot F.J.,Dillon A.J.P.,Echeverrigaray S.,Barros L.,Ferreira I.C.F.R.,Henriques J.A.P.,Roesch-Ely M.
Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines
Food and Chemical Toxicology, 112, 383-392, 2018

23
Oliveira F.S.,Ribeiro A.,Barros L.,Calhelha R.C.,Barreira J.C.M.,Junior B.D.,Abreu R.M.V.,Barreiro M.F.,Ferreira I.C.F.R.
Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)
Journal of Functional Foods, 38, 214-220, 2017

24
Merski M.,Moreira C.,Abreu R.M.V.,Ramos M.J.,Fernandes P.A.,Martins L.M.,Pereira P.J.B.,Macedo-Ribeiro S.
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
Cell Death and Disease, 8, , 2017

25
Liberal Â.,Calhelha R.C.,Pereira C.,Adega F.,Barros L.,Dueñas M.,Santos-Buelga C.,Abreu R.M.V.,Ferreira I.C.F.R.
A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: Red, white, and pink
Food and Function, 7, 679-688, 2016

26
Guimarães R.,Calhelha R.C.,Froufe H.J.C.,Abreu R.M.V.,Carvalho A.M.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Wild Roman chamomile extracts and phenolic compounds: Enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase
Food and Function, 7, 79-83, 2016

27
Machado V.A.,Peixoto D.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Abreu R.M.V.,Ferreira I.C.F.R.,Soares R.,Queiroz M.J.R.P.
Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
Bioorganic and Medicinal Chemistry, 23, 6497-6509, 2015

28
Alves M.J.,Froufe H.J.C.,Costa A.F.T.,Santos A.F.,Oliveira L.G.,Osório S.R.M.,Abreu R.M.V.,Pintado M.,Ferreira I.C.F.R.
Docking studies in target proteins involved in antibacterial action mechanisms: Extending the knowledge on standard antibiotics to antimicrobial mushroom compounds
Molecules, 19, 1672-1684, 2014

29
Santos S.,Baptista C.S.,Abreu R.M.V.,Bastos E.,Amorim I.,Gut I.G.,Gärtner F.,Chaves R.
ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: A model for erbB-2 negative human breast cancer
PLoS ONE, 8, , 2013

30
Queiroz M.J.R.P.,Peixoto D.,Calhelha R.C.,Soares P.,Dos Santos T.,Lima R.T.,Campos J.F.,Abreu R.M.V.,Ferreira I.C.F.R.,Vasconcelos M.H.
New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death
European Journal of Medicinal Chemistry, 69, 855-862, 2013

31
Soares P.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Peixoto D.,Ferreira I.C.F.R.,Abreu R.M.V.,Soares R.,Queiroz M.J.R.P.
1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies
BioMed Research International, 2013, , 2013

32
Froufe H.J.C.,Abreu R.M.V.,Ferreira I.C.F.R.
Virtual screening of low molecular weight mushrooms compounds as potential Mdm2 inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 28, 569-575, 2013

33
Alves M.J.,Ferreira I.C.F.R.,Froufe H.J.C.,Abreu R.M.V.,Martins A.,Pintado M.
Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies
Journal of Applied Microbiology, 115, 346-357, 2013

34
Rodrigues S.,Calhelha R.C.,Barreira J.C.M.,Dueñas M.,Carvalho A.M.,Abreu R.M.V.,Santos-Buelga C.,Ferreira I.C.F.R.
Crataegus monogyna buds and fruits phenolic extracts: Growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC-DAD-ESI/MS
Food Research International, 49, 516-523, 2012

35
Calhelha R.C.,Ferreira I.C.F.R.,Peixoto D.,Abreu R.M.V.,Vale-Silva L.A.,Pinto E.,Lima R.T.,Alvelos M.I.,Vasconcelos M.H.,Queiroz M.J.R.P.
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells
Molecules, 17, 3834-3843, 2012

36
Abreu R.M.V.,Froufe H.J.C.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Selective Flexibility of Side-Chain Residues Improves VEGFR-2 Docking Score using AutoDock Vina
Chemical Biology and Drug Design, 79, 530-534, 2012

37
Froufe H.J.C.,Abreu R.M.V.,Ferreira I.C.F.R.
QCAR models to predict wild mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition
Chemometrics and Intelligent Laboratory Systems, 109, 192-196, 2011

38
Abreu R.M.V.,Ferreira I.C.F.R.,Calhelha R.C.,Lima R.T.,Vasconcelos M.H.,Adega F.,Chaves R.,Queiroz M.J.R.P.
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies
European Journal of Medicinal Chemistry, 46, 5800-5806, 2011

39
Abreu R.M.V.,Froufe H.J.C.,Daniel P.O.M.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Chemt, an open-source software for building template-based chemical libraries
SAR and QSAR in Environmental Research, 22, 603-610, 2011

40
Froufe H.J.C.,Abreu R.M.V.,Ferreira I.C.F.R.
Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms
SAR and QSAR in Environmental Research, 22, 315-328, 2011

41
Abreu R.M.V.,Froufe H.J.C.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
MOLA: A bootable, self-configuring system for virtual screening using AutoDock4/Vina on computer clusters
Journal of Cheminformatics, 2, , 2010

42
Ferreira I.C.F.R.,Barros L.,Abreu R.M.V.
Antioxidants in wild mushrooms
Current Medicinal Chemistry, 16, 1543-1560, 2009

43
Abreu R.M.V.,Ferreira I.C.F.R.,Queiroz M.J.R.P.
QSAR model for predicting radical scavenging activity of di(hetero)arylamines derivatives of benzo[b]thiophenes
European Journal of Medicinal Chemistry, 44, 1952-1958, 2009

44
Abreu R.,Falcão S.,Calhelha R.C.,Ferreira I.C.F.R.,Queiroz M.J.R.P.,Vilas-Boas M.
Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile
Journal of Electroanalytical Chemistry, 628, 43-47, 2009

45
Froufe H.J.C.,Abreu R.M.V.,Ferreira I.C.F.R.
A QCAR model for predicting antioxidant activity of wild mushrooms
SAR and QSAR in Environmental Research, 20, 579-590, 2009

46
Abreu R.M.V.,Santos D.J.S.L.,Moreno A.J.M.
Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress
Journal of Pharmacology and Experimental Therapeutics, 295, 1022-1030, 2000

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Centro de Investigação de Montanha
Campus Santa Apolónia / 5300-253 Bragança
Phone: 273 303 382
Email: cimo@ipb.pt

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