ForestFisher aims to identify priority areas for conservation and restoration of Amazonian forestfrugivorous fish interactions and related ecosystem services. Climatically suitable areas for frugivorous fish species, riparian vegetation, connectivity will be integrated within the hydrographic network, and the location of current fishing grounds to define conserved and degraded climatic refugia, and infer the needs of potentially displaced fisher communities. The Amazon is at the centre of an ongoing intense international debate as highlighted in the recent COP-26 and ForestFisher will offer an approach to assess the combined effects of multiple threats on fish species. Fish species are essential to the functioning of a socio-economic system, as they offer food and income for indigenous peoples and local communities, and to the ecological processes needed for forest sustainability. From this assessment, and the inclusion of stakeholders (e.g. the Brazilian National Centre for Monitoring and Alerts of Natural Disasters, the NGO Ecoporé) and fishing communities, the project will finally offer an integrated strategy for the conservation and restoration of priority areas, contributing to successful mitigation of current and future changes and to the resilience of socio-ecological systems in the region.